The role of myeloid cells in thromboinflammatory disease

D Noone, RJS Preston, AM Rehill - Seminars in Thrombosis …, 2024 - thieme-connect.com
Inflammation contributes to the development of thrombosis, but the mechanistic basis for this
association remains poorly understood. Innate immune responses and coagulation …

Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon

TAJ Ryan, A Hooftman, AM Rehill… - Nature …, 2023 - nature.com
Excessive inflammation-associated coagulation is a feature of infectious diseases, occurring
in such conditions as bacterial sepsis and COVID-19. It can lead to disseminated …

Trained Immunity Causes Myeloid Cell Hypercoagulability

AM Rehill, S McCluskey, AE Ledwith, TAJ Ryan… - bioRxiv, 2024 - biorxiv.org
Venous thromboembolism is common in individuals with chronic inflammatory diseases, but
the pathogenic basis for this increased thrombotic risk remains poorly understood. Myeloid …