Gene therapy for hearing loss

R Omichi, SB Shibata, CC Morton… - Human molecular …, 2019 - academic.oup.com
Sensorineural hearing loss (SNHL) is the most common sensory disorder. Its underlying
etiologies include a broad spectrum of genetic and environmental factors that can lead to …

Bioengineered cellular and cell membrane-derived vehicles for actively targeted drug delivery: so near and yet so far

MY Thanuja, C Anupama, SH Ranganath - Advanced drug delivery reviews, 2018 - Elsevier
Cellular carriers for drug delivery are attractive alternatives to synthetic nanoparticles owing
to their innate homing/targeting abilities. Here, we review molecular interactions involved in …

Bioactive injectable hydrogels containing desferrioxamine and bioglass for diabetic wound healing

L Kong, Z Wu, H Zhao, H Cui, J Shen… - … applied materials & …, 2018 - ACS Publications
Diabetic wound is hard to heal mainly because of the difficulty in vascularization in the
wound area. Accumulating results have shown that desferrioxamine (DFO) can promote …

[HTML][HTML] Mesenchymal stem cell-derived exosomal miR-223 regulates neuronal cell apoptosis

H Wei, Y Xu, Q Chen, H Chen, X Zhu, Y Li - Cell death & disease, 2020 - nature.com
Hypoxia limits the survival and function of neurons in the development of Alzheimer's
diseases. Exosome-dependent intercellular communication is an emerging signaling …

Insight in Hypoxia‐Mimetic Agents as Potential Tools for Mesenchymal Stem Cell Priming in Regenerative Medicine

A Nowak-Stępniowska, PN Osuchowska… - Stem Cells …, 2022 - Wiley Online Library
Hypoxia‐mimetic agents are new potential tools in MSC priming instead of hypoxia
incubators or chambers. Several pharmaceutical/chemical hypoxia‐mimetic agents can be …

[HTML][HTML] Inner ear drug delivery for sensorineural hearing loss: current challenges and opportunities

SS Liu, R Yang - Frontiers in Neuroscience, 2022 - frontiersin.org
Most therapies for treating sensorineural hearing loss are challenged by the delivery across
multiple tissue barriers to the hard-to-access anatomical location of the inner ear. In this …

Advances in Hypoxia-Inducible Factor-1α Stabilizer Deferoxamine in Tissue Engineering

Y Zhu, B Chang, Y Pang, H Wang… - Tissue Engineering Part B …, 2023 - liebertpub.com
Deferoxamine (DFO) is an iron chelator with FDA approval for the clinical treatment of iron
excess. As a well-established stabilizer of hypoxia-inducible factor-1α (HIF-1α), DFO can …

[HTML][HTML] The role of HIF-1α in bone regeneration: a new direction and challenge in bone tissue engineering

J You, M Liu, M Li, S Zhai, S Quni, L Zhang… - International Journal of …, 2023 - mdpi.com
The process of repairing significant bone defects requires the recruitment of a considerable
number of cells for osteogenesis-related activities, which implies the consumption of a …

Preconditioning of umbilical cord‐derived mesenchymal stem cells by rapamycin increases cell migration and ameliorates liver ischaemia/reperfusion injury in mice …

J Zheng, H Li, L He, Y Huang, J Cai, L Chen… - Cell …, 2019 - Wiley Online Library
Objectives Transfusion of umbilical cord‐derived mesenchymal stem cells (UC‐MSCs) is a
novel strategy for treatment of various liver diseases. However, the therapeutic effect of UC …

Mechanisms of oxidative stress in methylmercury-induced neurodevelopmental toxicity

X Li, J Pan, Y Wei, L Ni, B Xu, Y Deng, T Yang, W Liu - Neurotoxicology, 2021 - Elsevier
Methylmercury (MeHg) is a long-lasting organic environmental pollutant that poses a great
threat to human health. Ingestion of seafood containing MeHg is the most important way by …