A significant body of evidence supports the protective role of exercise training (ET) in
cardiovascular diseases, skeletal muscle dystrophies, several types of cancer, Alzheimer …

For decades, we have known that exercise training exerts beneficial effects on the human
body, and clear evidence is available that a higher fitness level is associated with a lower …

In the natural habitat of our ancestors, physical activity was not a preventive intervention but
a matter of survival. In this hostile environment with scarce food and ubiquitous dangers …

Rationale: Sympathetic stimulation of the heart increases the force of contraction and rate of
ventricular relaxation by triggering protein kinase (PK) A-dependent phosphorylation of …

Background Heart failure (HF) is known to lead to skeletal muscle atrophy and dysfunction.
However, intracellular mechanisms underlying HF-induced myopathy are not fully …

Clinical consequences of heart failure are fatigue, dyspnea, and progressive impairment of
exercise tolerance. Regular exercise training is associated with health-improving effects. In …

Epidemiological studies in large cohorts support the notion that physical fitness is
associated with reduced cardiovascular mortality and hospitalization due to cardiovascular …

Cardiomyocyte hypertrophy occurs in response to a variety of physiological and pathological
stimuli. While pathological hypertrophy in heart failure is usually coupled with depressed …

The effect of endurance training (swimming 90 min/d for 5 days a week for 60 days) on
cardiac hypertrophy was investigated in the spontaneously hypertensive rat (SHR) …

Regular exercise and a physically active lifestyle have favorable effects on health. Several
issues related to this theme are addressed in this report. A comment on the requirements of …