Abstract 'Autophagy'refers to an evolutionarily conserved process through which cellular
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …

Primary microcephaly (MCPH, for “microcephaly primary hereditary”) is a disorder of brain
development that results in a head circumference more than 3 standard deviations below …

Exosomes are secreted nanovesicles with potent signalling activity that are initially formed
as intraluminal vesicles (ILVs) in late Rab7‐positive multivesicular endosomes, and also in …

The hedgehog (Hh) family comprises sonic hedgehog (Shh), Indian hedgehog (Ihh), and
desert hedgehog (Dhh), which are versatile signaling molecules involved in a wide …

Comparisons of DNA from archaic and modern humans show that these groups interbred,
and in some cases received an evolutionary advantage from doing so. This process …

The mammalian cerebellum is located in the posterior cranial fossa and is critical for motor
coordination and non-motor functions including cognitive and emotional processes. The …

Background Parkinson's disease (PD) is a neurodegenerative movement disorder affecting
1–5% of the general population for which neither effective cure nor early diagnostic tools are …

Abstract cGAS‐STING signalling is induced by detection of foreign or mislocalised host
double‐stranded (ds) DNA within the cytosol. STING acts as the major signalling hub, where …

Background Pontocerebellar hypoplasia (PCH) describes a rare, heterogeneous group of
neurodegenerative disorders mainly with a prenatal onset. Patients have severe hypoplasia …

The frequency and importance of the evaluation of the posterior fossa have increased
significantly over the past 20 years owing to advances in neuroimaging. Nowadays …