The tremendous therapeutic potential of voltage-gated sodium channels (Navs) has been
the subject of many studies in the past and is of intense interest today. Nav1. 7 channels in …

Voltage-gated calcium (Ca2+) channels are key transducers of membrane potential
changes into intracellular Ca2+ transients that initiate many physiological events. There are …

Voltage-gated sodium channel Na v 1.5 generates cardiac action potentials and initiates the
heartbeat. Here, we report structures of Na V 1.5 at 3.2–3.5 Å resolution. Na V 1.5 is …

Mechanotransduction has an important role in physiology. Biological processes including
sensing touch and sound waves require as-yet-unidentified cation channels that detect …

Voltage-gated sodium (NaV) channels initiate electrical signalling in excitable cells and are
the molecular targets for drugs and disease mutations, but the structural basis for their …

Voltage‐gated sodium channels initiate action potentials in nerve, muscle and other
excitable cells. The sodium current that initiates the nerve action potential was discovered by …

Metal cations are indispensable components of the cellular machinery and are involved in
numerous essential tasks ranging from nucleic acid and protein structure stabilization to …

Voltage-gated sodium and calcium channels are evolutionarily related transmembrane
signaling proteins that initiate action potentials, neurotransmission, excitation-contraction …

Voltage-gated sodium channels are responsible for the rising phase of the action potential in
the membranes of neurons and most electrically excitable cells. Exploration of the molecular …

In nanopore analytics, individual molecules pass through a single nanopore giving rise to
detectable temporary blockades in ionic pore current. Reflecting its simplicity, nanopore …