Comorbidities are a hallmark of stroke that both increase the incidence of stroke and worsen
outcome. Hypertension is prevalent in the stroke population and the most important …

Abstract Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is a global health threat. Some COVID-19 patients …

Leukocytes are recruited into the cerebral microcirculation following an ischemic insult. The
leukocyte–endothelial cell adhesion manifested within a few hours after ischemia (followed …

Several lines of clinical and experimental evidence suggest an important role of the
reninangiotensin system in ischemic brain injury although the cellular regulation of the …

The renin angiotensin system (RAS) is intricately involved in normal cardiovascular
homeostasis. Excessive stimulation by the octapeptide angiotensin II contributes to a range …

Background—The role of angiotensin II receptor subtypes was investigated in focal brain
ischemia induced by middle cerebral artery (MCA) occlusion. Methods and Results—In …

Stroke disrupts the homeostatic balance within the brain and is associated with a significant
accumulation of necrotic cellular debris, fluid, and peripheral immune cells in the central …

Angiotensin II (AII) plays a major role in the progression of inflammation and NADPH-
derived oxidative stress (OS) in several tissues. The brain possesses a local angiotensin …

Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …

Background and Purpose—Leukoaraiosis (LA) is associated with structural and functional
vascular changes that may compromise tissue perfusion at the microvascular level. We …