Mitral valve disease is a frequent cause of heart failure and death. Emerging evidence
indicates that the mitral valve is not a passive structure, but—even in adult life—remains …

Delling and Vasan Epidemiology and Pathophysiology of MVP 2159 called classic prolapse,
whereas prolapse with lesser degrees of leaflet thickening is regarded as nonclassic …

Mitral valve prolapse (MVP) is a common cardiac valve disease that affects nearly 1 in 40
individuals,,. It can manifest as mitral regurgitation and is the leading indication for mitral …

Elevated transforming growth factor (TGF)-β signaling has been implicated in the
pathogenesis of syndromic presentations of aortic aneurysm, including Marfan syndrome …

The importance of the epicardium for myocardial and valvuloseptal development has been
well established; perturbation of epicardial development results in cardiac abnormalities …

Defective mitochondrial dynamics through aberrant interactions between mitochondria and
actin cytoskeleton is increasingly recognized as a key determinant of cardiac fragility after …

Cardiac regeneration, that is, restoration of the original structure and function in a damaged
heart, differs from tissue repair, in which collagen deposition and scar formation often lead to …

Nonsyndromic mitral valve prolapse (MVP) is a common degenerative cardiac valvulopathy
of unknown etiology that predisposes to mitral regurgitation, heart failure and sudden death …

The calponin homology (CH) domain is one of the most common modules in various actin-
binding proteins and is characterized by an α-helical fold. The CH domain plays important …

Mitral valve prolapse (MVP) is a common condition that affects 2%–3% of the general
population. MVP is thought to include syndromic forms such as Marfan syndrome and non …