The early endosome (EE), also known as the sorting endosome (SE) is a crucial station for
the sorting of cargoes, such as receptors and lipids, through the endocytic pathways. The …

Exosomes are extracellular vesicles released upon fusion of multivesicular bodies (MVBs)
with the cellular plasma membrane. They originate as intraluminal vesicles (ILVs) during the …

Intracellular transport is fundamental for cellular function, survival and morphogenesis.
Kinesin superfamily proteins (also known as KIFs) are important molecular motors that …

Endocytic recycling is coordinated with endocytic uptake to control the composition of the
plasma membrane. Although much of our understanding of endocytic recycling has come …

Live-cell imaging reveals the endolysosomal system as a complex and highly dynamic
network of interacting compartments. Distinct types of endosomes are discerned by kinetic …

The organization of cells into interconnected structures such as animal tissues requires a
sophisticated system directing receptors and adhesion proteins to the cell surface. The …

The endocytic pathway is essential for processes that define how cells interact with their
environment, including receptor signalling, cell adhesion and migration, pathogen entry …

The endosomal recycling pathway lies at the heart of the membrane trafficking machinery in
the cell. It plays a central role in determining the composition of the plasma membrane and …

Rab proteins represent the largest branch of the Ras-like small GTPase superfamily and
there are 66 Rab genes in the human genome. They alternate between GTP-and GDP …

The asymmetric polarization of cells allows specialized functions to be performed at discrete
subcellular locales. Spatiotemporal coordination of polarization between groups of cells …