The default mode network (DMN) is a set of widely distributed brain regions in the parietal,
temporal and frontal cortex. These regions often show reductions in activity during attention …

Since the first place cell was recorded and the cognitive-map theory was subsequently
formulated, investigation of spatial representation in the hippocampal formation has evolved …

We developed a miniaturized two-photon microscope (MINI2P) for fast, high-resolution,
multiplane calcium imaging of over 1,000 neurons at a time in freely moving mice. With a …

Sensory, motor and cognitive operations involve the coordinated action of large neuronal
populations across multiple brain regions in both superficial and deep structures,. Existing …

Grid cells in the medial entorhinal cortex have spatial firing fields that repeat periodically in a
hexagonal pattern. When animals move, activity is translated between grid cells in …

The mammalian hippocampus is important for normal memory function, particularly memory
for places and events. Place cells, neurons within the hippocampus that have spatial …

The brain creates a model of the world around us. We can use this representation to
perceive and comprehend what we see at any given moment, but also to vividly re …

The discovery of neuronal systems dedicated to computing spatial information, composed of
functionally distinct cell types such as place and grid cells, combined with an extensive body …

The hippocampal system is critical for storage and retrieval of declarative memories,
including memories for locations and events that take place at those locations. Spatial …

Theories on the functions of the hippocampal system are based largely on two fundamental
discoveries: the amnestic consequences of removing the hippocampus and associated …