ROS are a group of small reactive molecules that play critical roles in the regulation of
various cell functions and biological processes. In the vascular system, physiological levels …

Abdominal aortic aneurysm (AAA) affects approximately 5% of elderly men and is
responsible for a significant number of deaths in Western Countries. At present surgery by …

Background: Large-scale human and mechanistic mouse studies indicate a strong
relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) …

The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E2. It
belongs to the family of G protein–coupled receptors. It was originally identified, similar to …

Macrophage polarization plays a crucial role in regulating abdominal aortic aneurysm (AAA)
formation. Circular RNAs (circRNAs) are important regulators of macrophage polarization …

The role of inflammation in the pathogenesis of abdominal aortic aneurysms (AAA) is well
established. The inflammatory process leads to protease-mediated degradation of the …

Objective—Obesity promotes macrophage infiltration into adipose tissue and is associated
with increases in several cardiovascular diseases. Infusion of angiotensin II (AngII) to mice …

INTRODUCTION: Cardiovascular disease, the leading cause of death in much of the
modern world, is the common symptomatic end stage of a number of distinct diseases and …

Prostacyclin, or PGI2, is an end product derived from the sequential metabolism of
arachidonic acid via cyclooxygenase and PGI synthase (PGIS). The receptor for PGI2, IP …

BACKGROUND AND PURPOSE Cerebral aneurysm is a frequent cerebrovascular event
and a major cause of fatal subarachnoid haemorrhage, but there is no medical treatment for …