The field of extracellular vesicle (EV) research has developed rapidly over the last decade
from the study of fundamental biology to a subject of significant clinical relevance. The …

The daily removal of billions of apoptotic cells in the human body via the process of
efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid …

Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

Cancer growth represents a dysregulated imbalance between cell gain and cell loss, where
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …

Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

The clearance of apoptotic cells by professional and non-professional phagocytes—a
process termed 'efferocytosis'—is essential for the maintenance of tissue homeostasis …

Macrophages are the gatekeepers of intestinal immune homeostasis as they discriminate
between innocuous antigens and potential pathogens to maintain oral tolerance. However …

There is growing evidence that excessive microglial phagocytosis of neurons and synapses
contributes to multiple brain pathologies. RNA‐seq and genome‐wide association (GWAS) …

Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …

The many functions of extracellular vesicles (EVs) like exosomes and microvesicles
released from healthy cells have been well characterized, particularly in relation to their …