The involvement of the PIK3CA gene product p110α, the catalytic subunit of
phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 …

Abstract The phosphatidylinositol 3-kinase (PI3K) pathway is commonly deregulated in
cancer. In recent years, the results of the first phase I clinical trials with PI3K inhibitors have …

Penile squamous cell carcinoma (PSCC) accounts for over 95% of penile malignancies and
causes significant mortality and morbidity in developing countries. Molecular mechanisms …

Objective To evaluate the safety and efficacy of epidermal growth factor receptor (EGFR)‐
targeted therapy in patients with advanced penile or scrotal cancer. Patients and Methods …

Background Penile cancer (PC) is a rare cancer in western countries, but is more common in
parts of the developing world. Due to its rarity and the consequent lack of randomized trials …

Penile squamous cell carcinoma is a rare malignancy with various distinct histological
subtypes, each with distinct appearances, histotypic specific associations with human …

Answer questions and earn CME/CNE Squamous cell carcinoma (SCC) of the penis is a
rare malignancy in the United States, with a significantly higher incidence—up to 20 to 30 …

Human papillomaviruses (HPV) are widespread DNA viruses that can infect epithelial cells
of the skin and mucosa. Most HPV infections remain clinically unapparent and clear …

Background The pathogenesis of penile squamous cell carcinoma (PSCC) is not well
understood, though risk factors include human papillomavirus (HPV). Disruption of …

Please cite this paper as: Activation of the PI3K/AKT signalling pathway in non‐melanoma
skin cancer is not mediated by oncogenic PIK3CA and AKT1 hotspot mutations …