Melatonin as an adjuvant in radiotherapy for radioprotection and radiosensitization

B Farhood, NH Goradel, K Mortezaee… - Clinical and …, 2019 - Springer
It is estimated that more than half of cancer patients undergo radiotherapy during the course
of their treatment. Despite its beneficial therapeutic effects on tumor cells, exposure to high …

The role of nutrition in space exploration: Implications for sensorimotor, cognition, behavior and the cerebral changes due to the exposure to radiation, altered gravity …

SR Zwart, AP Mulavara, TJ Williams, K George… - Neuroscience & …, 2021 - Elsevier
Multi-year crewed space exploration missions are now on the horizon; therefore, it is
important that we understand and mitigate the physiological effects of spaceflight. The …

Vitamins and radioprotective effect: a review

I Lledó, B Ibáñez, A Melero, A Montoro… - Antioxidants, 2023 - mdpi.com
The radioprotective effect ex vivo, in vitro and in vivo of vitamins was reviewed using
PubMed and Embase and conducted according to the PRISMA statement. A total of 38 …

[HTML][HTML] Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy

MS Petronek, JM Stolwijk, SD Murray, EJ Steinbach… - Redox biology, 2021 - Elsevier
There is a rapidly growing body of literature supporting the notion that differential oxidative
metabolism in cancer versus normal cells represents a metabolic frailty that can be exploited …

The effect of zinc and melatonin supplementation on immunity parameters in breast cancer induced by DMBA in rats

SB Baltaci, R Mogulkoc, AK Baltaci… - … of physiology and …, 2018 - Taylor & Francis
Objective: The aim of the study was to determine the effects of zinc and melatonin
supplements on the immunity parameters of female rats with breast cancer induced by …

Protective effect of melatonin against radiotherapy-induced small intestinal oxidative stress: biochemical evaluation

AE Musa, D Shabeeb, HSQ Alhilfi - Medicina, 2019 - mdpi.com
Background and Objectives: Radiation enteritis is a common side effect after radiotherapy
for abdominal and pelvic malignancies. The aim of the present study was to investigate the …

Study logistics that can impact medical countermeasure efficacy testing in mouse models of radiation injury

AL DiCarlo, Z Perez Horta, CI Rios… - … journal of radiation …, 2021 - Taylor & Francis
Purpose To address confounding issues that have been noted in planning and conducting
studies to identify biomarkers of radiation injury, develop animal models to simulate these …

The radioprotective effects of melatonin and nanoselenium on DNA double-strand breaks in peripheral lymphocytes caused by I-131

SM Jafarpour, B Shekarchi, H Bagheri… - Indian Journal of …, 2021 - journals.lww.com
Background: One of the treatment modalities for thyroid cancer and hyperthyroidism is
radioiodine-131 (I-131) therapy. The use of this therapeutic modality is not completely safe …

Celecoxib mitigates genotoxicity induced by ionizing radiation in human blood lymphocytes

SJ Hosseinimehr, M Fathi, A Ghasemi… - Research in …, 2017 - journals.lww.com
Ionizing radiation causes DNA damage and chromosome abbreviations on normal cells.
The radioprotective effect of celecoxib (CLX) was investigated against genotoxicity induced …

The radioprotective effect of melatonin against radiation-induced DNA double-strand breaks in radiology

F Esmaely, A Mahmoudzadeh, M Cheki… - Journal of Cancer …, 2020 - journals.lww.com
Objective: The objective of this study is to observe the effect of 100-mg melatonin in reducing
the levels of double-strand breaks (DSB) induced by 10 mGy and 100 mGy X-ray in …