[HTML][HTML] Fundus-controlled perimetry (microperimetry): application as outcome measure in clinical trials
Fundus-controlled perimetry (FCP, also called 'microperimetry') allows for spatially-resolved
mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as …
mapping of visual sensitivity and measurement of fixation stability, both in clinical practice as …
[HTML][HTML] Endpoints for clinical trials in ophthalmology
With the identification of novel targets, the number of interventional clinical trials in
ophthalmology has increased. Visual acuity has for a long time been considered the gold …
ophthalmology has increased. Visual acuity has for a long time been considered the gold …
Clinical perspectives and trends: microperimetry as a trial endpoint in retinal disease
Y Yang, H Dunbar - Ophthalmologica, 2021 - karger.com
Endpoint development trials are underway across the spectrum of retinal disease. New
validated endpoints are urgently required for the assessment of emerging gene therapies …
validated endpoints are urgently required for the assessment of emerging gene therapies …
[HTML][HTML] CRB1-associated retinal dystrophies: a prospective natural history study in anticipation of future clinical trials
M Talib, MJ van Schooneveld, J Wijnholds… - American Journal of …, 2022 - Elsevier
PURPOSE To investigate the natural disease course of retinal dystrophies associated with
crumbs cell polarity complex component 1 (CRB1) and identify clinical end points for future …
crumbs cell polarity complex component 1 (CRB1) and identify clinical end points for future …
Stargardt disease and progress in therapeutic strategies
Background Stargardt disease (STGD1) is an autosomal recessive retinal dystrophy due to
mutations in ABCA4, characterized by subretinal deposition of lipofuscin-like substances …
mutations in ABCA4, characterized by subretinal deposition of lipofuscin-like substances …
[HTML][HTML] Microperimetry in retinal diseases
S Horie, C Giulia, H Esmaeilkhanian… - Asia-Pacific Journal of …, 2023 - Elsevier
Retinal microperimetry (MP) is a procedure that assesses the retinal sensitivity while the
fundus is directly observed, and an eye tracker system is active to compensate for …
fundus is directly observed, and an eye tracker system is active to compensate for …
Natural history of visual dysfunction in ABCA4 Retinopathy and its genetic correlates
PURPOSE To systematically assess the ability to detect change and retest reliability for a
panel of visual function assessments in ABCA4 retinopathy. DESIGN Prospective natural …
panel of visual function assessments in ABCA4 retinopathy. DESIGN Prospective natural …
The role of multimodal imaging and vision function testing in ABCA4-related retinopathies and their relevance to future therapeutic interventions
S Al-Khuzaei, M Shah, CR Foster, J Yu… - Therapeutic …, 2021 - journals.sagepub.com
The aim of this review article is to describe the specific features of Stargardt disease and
ABCA4 retinopathies (ABCA4R) using multimodal imaging and functional testing and to …
ABCA4 retinopathies (ABCA4R) using multimodal imaging and functional testing and to …
The progression of Stargardt disease using volumetric hill of vision analyses over 24 months: ProgStar Report No. 15
EM Schönbach, L Janeschitz-Kriegl, RW Strauss… - American journal of …, 2021 - Elsevier
Purpose To report the yearly rate of change in macular function in patients with Stargardt
disease type 1 (STGD1) over 24 months and to establish a new volumetric visual function …
disease type 1 (STGD1) over 24 months and to establish a new volumetric visual function …
Retinal Imaging Findings in Inherited Retinal Diseases
Inherited retinal diseases (IRDs) represent one of the major causes of progressive and
irreversible vision loss in the working-age population. Over the last few decades, advances …
irreversible vision loss in the working-age population. Over the last few decades, advances …