Physical and mechanical properties of ocular thin films: a systematic review and meta-analysis

M Farahmandnejad, S Alipour, A Nokhodchi - Drug Discovery Today, 2024 - Elsevier
The ocular thin film presents a potential solution for addressing challenges to ocular drug
delivery. In this review, we summarise the findings of a comprehensive review analysing 336 …

Dress me an outfit: advanced probiotics hybrid systems for intelligent IBD therapy

Y Li, Y Wang, Y Li, S Yan, X Gao, P Li… - Critical Reviews in …, 2024 - Taylor & Francis
Inflammation bowel disease (IBD) has emerged as a public health challenge worldwide;
with high incidence and rapid prevalence, it has troubled billions of people and further …

Nanocarriers significantly augment the absorption of ocular-delivered drugs: A comparative meta-analysis study

GM El Zaafarany, RM Hathout, SS Ibrahim - International Journal of …, 2023 - Elsevier
This study presents a meta-analysis that compiles information collected from several studies
aiming to prove, by evidence, that nanocarriers out-perform conventional formulations in …

Eudragit films as carriers of lipoic acid for transcorneal permeability

KL Bierbrauer, LR Comini, V Leonhard… - Polymers, 2023 - mdpi.com
Diabetes mellitus (DM) is a highly prevalent disease affecting almost 10% of the world
population; it is characterized by acute and chronic conditions. Diabetic patients have twenty …

[HTML][HTML] Thermosensitive Polyhedral Oligomeric Silsesquioxane Hybrid Hydrogel Enhances the Antibacterial Efficiency of Erythromycin in Bacterial Keratitis

L Zheng, Y Chen, Y Han, J Lin, K Fan… - Biomaterials …, 2024 - spj.science.org
Bacterial keratitis is a serious ocular infection that can impair vision or even cause
blindness. The clinical use of antibiotics is limited due to their low bioavailability and drug …

MeltSerts technology (brinzolamide ocular inserts via hot-melt extrusion): QbD-steered development, molecular dynamics, in vitro, ex vivo and in vivo studies

S Tambe, D Jain, R Rawat, S Mali, MA Pagano… - International Journal of …, 2023 - Elsevier
The research work aimed to develop a robust sustained release biocompatible brinzolamide
(BRZ)-loaded ocular inserts (MeltSerts) using hot-melt extrusion technology with enhanced …

[HTML][HTML] Thermosensitive Polyhedral Oligomeric Silsesquioxane Hybrid Hydrogel Enhances the Antibacterial Efficiency of Erythromycin in Bacterial Keratitis

L Zheng, Y Chen, Y Han, J Lin, K Fan… - Biomaterials …, 2024 - ncbi.nlm.nih.gov
Bacterial keratitis is a serious ocular infection that can impair vision or even cause
blindness. The clinical use of antibiotics is limited due to their low bioavailability and drug …

[HTML][HTML] Macrolide-loaded nanofibrous inserts with polycaprolactone and cellulose acetate base for sustained ocular delivery: Pharmacokinetic study in Rabbit's eye

S Taghe, S Mirzaeei, N Pakdaman, A Kazemi… - International Journal of …, 2024 - Elsevier
The present study aimed to prepare nanofibrous inserts for sustained ocular drug delivery of
Azithromycin (AZM) toward conquering the obstacles of conventional topical drug delivery …

Release of delta-9-tetrahydrocannabinol from polyvinyl alcohol hydrogels and its safe interaction with human skin fibroblasts

S Cui, Z Zhang, D Rodrigue, F Béland… - Frontiers in Drug …, 2024 - frontiersin.org
This study aimed to design a THC-rich hydrogel to deliver cannabis derivatives topically. We
developed hydrogels using polyvinyl alcohol (PVA) mixed with propylene glycol (PG) …

Fabrication of Anti-glaucoma Nanofibers as Controlled-Release Inserts for Ophthalmic Delivery of Brimonidine Tartrate: In Vivo Evaluation in Caprine Eye

FS Shoushtari, M Naghshbandy, L Rezaei… - Advanced …, 2024 - apb.tbzmed.ac.ir
Purpose: Chronic ailments usually decrease the quality of life due to the requirement for
repetitive administration of drugs. Glaucoma is a chronic eye disease occurred because of …