Insights into colonic protein fermentation, its modulation and potential health implications
Background Beneficial effects of carbohydrate fermentation on gastrointestinal health are
well established. Conversely, protein fermentation generates harmful metabolites but their …
well established. Conversely, protein fermentation generates harmful metabolites but their …
Functional circuits and signal processing in the enteric nervous system
C Fung, P Vanden Berghe - Cellular and Molecular Life Sciences, 2020 - Springer
The enteric nervous system (ENS) is an extensive network comprising millions of neurons
and glial cells contained within the wall of the gastrointestinal tract. The major functions of …
and glial cells contained within the wall of the gastrointestinal tract. The major functions of …
Enteroendocrine cells sense bacterial tryptophan catabolites to activate enteric and vagal neuronal pathways
The intestinal epithelium senses nutritional and microbial stimuli using epithelial sensory
enteroendocrine cells (EEC). EECs communicate nutritional information to the nervous …
enteroendocrine cells (EEC). EECs communicate nutritional information to the nervous …
Revisiting the role of Akkermansia muciniphila as a therapeutic bacterium
Despite a short history since its first isolation, Akkermansia muciniphila has been extensively
studied in relation to its effects on human metabolism. A recent human intervention study …
studied in relation to its effects on human metabolism. A recent human intervention study …
The diverse metabolic roles of peripheral serotonin
Abstract Serotonin (5-hydroxytryptamine or 5-HT) is a multifunctional bioamine with
important signaling roles in a range of physiological pathways. Almost all of the 5-HT in our …
important signaling roles in a range of physiological pathways. Almost all of the 5-HT in our …
Critical review evaluating the pig as a model for human nutritional physiology
The present review examines the pig as a model for physiological studies in human subjects
related to nutrient sensing, appetite regulation, gut barrier function, intestinal microbiota and …
related to nutrient sensing, appetite regulation, gut barrier function, intestinal microbiota and …
Neuropod cells: the emerging biology of gut-brain sensory transduction
Guided by sight, scent, texture, and taste, animals ingest food. Once ingested, it is up to the
gut to make sense of the food's nutritional value. Classic sensory systems rely on …
gut to make sense of the food's nutritional value. Classic sensory systems rely on …
The L-cell in nutritional sensing and the regulation of appetite
E Spreckley, KG Murphy - Frontiers in nutrition, 2015 - frontiersin.org
The gastrointestinal (GI) tract senses the ingestion of food and responds by signaling to the
brain to promote satiation and satiety. Representing an important part of the gut–brain axis …
brain to promote satiation and satiety. Representing an important part of the gut–brain axis …
Of men and mice: modeling the fragile X syndrome
R Dahlhaus - Frontiers in molecular neuroscience, 2018 - frontiersin.org
The Fragile X Syndrome (FXS) is one of the most common forms of inherited intellectual
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …
disability in all human societies. Caused by the transcriptional silencing of a single gene, the …
The role of the gut microbiota in the gut–brain axis in obesity: mechanisms and future implications
J van Son, LL Koekkoek, SE La Fleur, MJ Serlie… - International Journal of …, 2021 - mdpi.com
Interaction between the gut and the brain is essential for energy homeostasis. In obesity, this
homeostasis is disrupted, leading to a positive energy balance and weight gain. Obesity is a …
homeostasis is disrupted, leading to a positive energy balance and weight gain. Obesity is a …