Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

The a 28-amino acid peptide ghrelin was discovered in 1999 as a growth hormone (GH)
releasing peptide. Soon after its discovery, ghrelin was found to increase body weight and …

Ghrelin is a gastric peptide hormone, discovered as being the endogenous ligand of growth
hormone secretagogue receptor. Ghrelin is a 28 amino acid peptide presenting a unique n …

Des-acyl ghrelin (DAG) is one of the three preproghrelin gene-encoded peptides. Compared
with ghrelin and obestatin, it has not received the attention it deserves. DAG has long been …

Context and objective Prader-Willi syndrome (PWS) is characterized by early-onset
hyperphagia and increased circulating levels of the orexigenic Acylated Ghrelin (AG) …

Diabetes mellitus, a disease that affects nearly 536.6 million people worldwide, is
characterized by the death or dysfunction of insulin-producing beta cells of the pancreas …

The only molecularly identified ghrelin receptor is the growth hormone secretagogue
receptor GHSR1a. Its natural ligand, ghrelin, is an acylated peptide whose unacylated …

Reactive oxygen species (ROS) are crucial in long-term diabetes complications, including
peripheral artery disease (PAD). In this study, we have investigated the potential clinical …

Background Surgical treatment of peripheral artery disease, even if successful, does not
prevent reoccurrence. Under these conditions, increased oxidative stress is a crucial …

Desacyl-ghrelin is a form of ghrelin which lacks acyl-modification of the third serine residue
of ghrelin. Originally, desacyl-ghrelin was considered to be just an inactive form of ghrelin …