In eukaryotic cells, mitochondria are involved in a large array of metabolic and bioenergetic
processes that are vital for cell survival. Phospholipids are the main building blocks of …

Cardiolipin is a unique phospholipid which is almost exclusively located in the inner
mitochondrial membrane where it is biosynthesized. Considerable progress has recently …

Cytochrome c (Cytc) plays a vital role in the mitochondrial electron transport chain (ETC). In
addition, it is a key regulator of apoptosis. Cytc has multiple other functions including ROS …

The mitochondrion is at the core of cellular energy metabolism, being the site of most ATP
generation. Calcium is a key regulator of mitochondrial function and acts at several levels …

Mitochondria are a quantitatively relevant source of reactive oxygen species (ROS) in the
majority of cell types. Here we review the sources and metabolism of ROS in this organelle …

This review focuses on key components of respiratory and photosynthetic energy-
transduction systems: the cytochrome bc 1 and b 6 f (Cyt bc 1/b 6 f) membranous …

Oxidative stress is considered a major contributor to etiology of both “normal” senescence
and severe pathologies with serious public health implications. Mitochondria generate …

Cytochrome c (Cytc) is essential in mitochondrial electron transport and intrinsic type II
apoptosis. Mammalian Cytc also scavenges reactive oxygen species (ROS) under healthy …

Reactive oxygen species (ROS) comprise the superoxide anion (O2•−), hydrogen peroxide
(H2O2), hydroxyl radical (• OH), and singlet oxygen (1O2). ROS can damage a variety of …

For a long time mitochondria have mainly been considered for their role in the aerobic
energy production in eukaryotic cells, being the sites of the oxidative phosphorylation, which …