Hematopoesis is a multi-stage process, which results in development of blood and immande
system's cells. Ikaros, which is coded by IKZF1 and Ikaros faimily zinc finger transcription …

The blood–brain barrier (BBB) is essential for proper neuronal function, homeostasis, and
protection of the central nervous system (CNS) microenvironment from blood-borne …

What is known and objective Variation in the expression of drug‐response‐related genes
contributes significantly to interindividual differences in drug response. DNA methylation is …

Aim The present study aimed to evaluate the effects of gene variants in key genes
influencing pharmacokinetic and pharmacodynamic of carbamazepine (CBZ) on the …

Aim: The present study aimed to evaluate the effects of SNPs of major transporter and
metabolizing enzyme genes on carbamazepine (CBZ) metabolism in Chinese patients with …

Objective Previous studies reported the associations between the ATP-binding cassette sub-
family B member 1 (ABCB1, also known as MDR1) polymorphisms and their haplotypes with …

Although the Pgp efflux transport protein is overexpressed in resected tissue of patients with
epilepsy, the presence of polymorphisms in MDR1/ABCB1 and MRP2/ABCC2 in patients …

This paper reviews the impact of genetic variability of drug metabolizing enzymes,
transporters, receptors, and pathways involved in chronic pain perception on the efficacy …

Background Genetic polymorphisms of drug efflux transporters as ATP-binding cassette
subfamily B, member 1 (ABCB1) have been suggested to modulate antiepileptic drugs …

Aims Carbamazepine can cause hypersensitivity reactions in~ 10% of patients. An
immunogenic effect can be produced by the electrophilic 10, 11‐epoxide metabolite but not …