An overview of the evidence and mechanisms of herb–drug interactions

PS Fasinu, PJ Bouic, B Rosenkranz - Frontiers in pharmacology, 2012 - frontiersin.org
Despite the lack of sufficient information on the safety of herbal products, their use as
alternative and/or complementary medicine is globally popular. There is also an increasing …

Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders

ZJ Zhang - Life sciences, 2004 - Elsevier
A search for novel pharmacotherapy from medicinal plants for psychiatric illnesses has
progressed significantly in the past decade. This is reflected in the large number of herbal …

Potential medicinal plants for CNS disorders: an overview

V Kumar - … Research: An International Journal Devoted to …, 2006 - Wiley Online Library
Although very few drugs are currently approved by regulatory authorities for treating multi‐
factorial ailments and disorders of cognition such as Alzheimer's disease, certain plant …

Dietary supplementation of gingerols-and shogaols-enriched ginger root extract attenuate pain-associated behaviors while modulating gut microbiota and metabolites …

CL Shen, R Wang, G Ji, MM Elmassry… - The Journal of nutritional …, 2022 - Elsevier
Neuroinflammation is a central factor in neuropathic pain (NP). Ginger is a promising
bioactive compound in NP management due to its anti-inflammatory property. Emerging …

[PDF][PDF] Phytochemicals having neuroprotective properties from dietary sources and medicinal herbs

GP Kumar, KR Anilakumar, S Naveen - Pharmacognosy Journal, 2015 - phcogj.com
Many neuropsychiatric and neurodegenerative disorders, such as Alzheimer's disease,
anxiety, cerebrovascular impairment, depression, seizures, Parkinson's disease, etc. are …

Opportunities and challenges of kava in lung cancer prevention

B Freeman, J Mamallapalli, T Bian, K Ballas… - International journal of …, 2023 - mdpi.com
Lung cancer is the leading cause of cancer-related deaths due to its high incidence, late
diagnosis, and limited success in clinical treatment. Prevention therefore is critical to help …

(−)-Epigallocatechin gallate attenuates acute stress responses through GABAergic system in the brain

N Adachi, S Tomonaga, T Tachibana… - European journal of …, 2006 - Elsevier
(−)-Epigallocatechin gallate (EGCG), a flavonoid, is the principal catechin found in green tea
and is distributed in the brain after tea consumption. The aim of the present study was to …

Cell and small animal models for phenotypic drug discovery

M Szabo, S Svensson Akusjärvi, A Saxena… - Drug Design …, 2017 - Taylor & Francis
The phenotype-based drug discovery (PDD) approach is re-emerging as an alternative
platform for drug discovery. This review provides an overview of the various model systems …

Meta‐analysis of the efficacy of the acetonic kava‐kava extract WS®1490 in patients with non‐psychotic anxiety disorders

S Witte, D Loew, W Gaus - Phytotherapy Research: An …, 2005 - Wiley Online Library
Introduction: The herbal medicinal product kava‐kava, used for treating anxiety disorders,
was assessed positively by the Cochrane Review. However, it was withdrawn from the …

Intracerebroventricular injection of l-arginine induces sedative and hypnotic effects under an acute stress in neonatal chicks

R Suenaga, S Tomonaga, H Yamane, I Kurauchi… - Amino acids, 2008 - Springer
l-Arginine participates in many important and diverse biochemical reactions associated with
the normal physiology of the organism. In the present study, we investigated the effect of …