SARS-CoV-2 infection and oxidative stress: Pathophysiological insight into thrombosis and therapeutic opportunities

MS Alam, DM Czajkowsky - Cytokine & Growth Factor Reviews, 2022 - Elsevier
The current coronavirus disease 2019 (COVID-19) pandemic has presented unprecedented
challenges to global health. Although the majority of COVID-19 patients exhibit mild-to-no …

Eosinophils as potential biomarkers in respiratory viral infections

I Macchia, V La Sorsa, F Urbani, S Moretti… - Frontiers in …, 2023 - frontiersin.org
Eosinophils are bone marrow-derived granulocytes that, under homeostatic conditions,
account for as much as 1-3% of peripheral blood leukocytes. During inflammation …

Anti‐IFN‐α/‐ω neutralizing antibodies from COVID‐19 patients correlate with downregulation of IFN response and laboratory biomarkers of disease severity

F Frasca, M Scordio, L Santinelli… - European journal of …, 2022 - Wiley Online Library
A significant number of COVID‐19 patients were shown to have neutralizing antibodies
(NAB) against IFN; however, NAB specificity, fluctuation over time, associations with …

RNA Sequencing in COVID-19 patients identifies neutrophil activation biomarkers as a promising diagnostic platform for infections

R Wargodsky, P Dela Cruz, J LaFleur, D Yamane… - PloS one, 2022 - journals.plos.org
Infection with the SARS-CoV2 virus can vary from asymptomatic, or flu-like with moderate
disease, up to critically severe. Severe disease, termed COVID-19, involves acute …

Essential metals, vitamins and antioxidant enzyme activities in COVID-19 patients and their potential associations with the disease severity

I Al-Saleh, N Alrushud, H Alnuwaysir, R Elkhatib… - Biometals, 2022 - Springer
The role of micronutrient deficiency in the pathogenesis of COVID-19 has been reviewed in
the literature; however, the data are limited and conflicting. This study investigated the …

[HTML][HTML] Platelet indices and platelet to lymphocyte ratio (PLR) as markers for predicting COVID-19 infection severity

R Ravindra, P Ramamurthy, A Kulkarni, K Suhail… - Cureus, 2022 - ncbi.nlm.nih.gov
Background Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)(or
coronavirus disease 2019; COVID-19) has caused a large number of infections across the …

The immune, inflammatory and hematological response in COVID-19 patients, according to the severity of the disease

F Trofin, EV Nastase, A Vâță, LS Iancu, C Luncă… - Microorganisms, 2023 - mdpi.com
Introduction: The aim of this study was to evaluate the immune and inflammatory responses
in COVID-19 patients by dosing specific IgM and IgG total antibodies and interleukin 6 …

Diagnostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in various respiratory diseases: a retrospective analysis

MA Man, L Davidescu, NS Motoc, RM Rajnoveanu… - Diagnostics, 2021 - mdpi.com
The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) ratio are two
extensively used inflammatory markers that have been proved very useful in evaluating …

Factors associated with disease severity of COVID‑19 in patients with type 2 diabetes mellitus

H Novida, SA Soelistyo, C Cahyani… - Biomedical …, 2022 - spandidos-publications.com
Diabetes mellitus causes a decline in immunological function, an increase in
proinflammatory cytokines, and a prothrombotic state, thus providing risk factors for the …

Correlation of lung damage on CT scan with laboratory inflammatory markers in COVID-19 patients: A single-center study from Romania

C Citu, OM Gorun, A Motoc, IM Citu, F Gorun… - Journal of Clinical …, 2022 - mdpi.com
(1) Background: This study aims to evaluate the association of CRP, NLR, IL-6, and
Procalcitonin with lung damage observed on CT scans;(2) Methods: A cross-sectional study …