A wide variety of viruses exploit furin and other proprotein convertases (PCs) of the
constitutive protein secretion pathway in order to regulate their cell entry mechanism and …

Dengue is a significant global health problem. Even though a vaccine against dengue is
now available, which is a notable achievement, its long-term protective efficacy against each …

Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly identified
betacoronavirus causing high morbidity and mortality in humans. The coronavirus spike (S) …

The spike protein is a focused target of COVID-19, a pandemic caused by SARS-CoV-2. A
12-nt insertion at S1/S2 in the spike coding sequence yields a furin cleavage site, which …

Dengue virus (DENV) belongs to the family Flaviviridae, genus Flavivirus. It is a single-
stranded positive-sense ribonucleic acid virus with 10,700 bases. The genus Flavivirus …

Influenza viruses are major human pathogens responsible for respiratory diseases affecting
millions of people worldwide and characterized by high morbidity and significant mortality …

The hemagglutinin (HA) is a prime determinant of the pathogenicity of influenza A viruses. It
initiates infection by binding to cell surface receptors and by inducing membrane fusion. The …

In many countries afflicted with dengue fever, traditional medicines are widely used as
panaceas for illness, and here we describe the systematic evaluation of a widely known …

Influenza A viruses of the subtype H9N2 circulate worldwide and have become highly
prevalent in poultry in many countries. Moreover, they are occasionally transmitted to …

Analysis of the SARS-CoV-2 sequence revealed a multibasic furin cleavage site at the
S1/S2 boundary of the spike protein distinguishing this virus from SARS-CoV. Furin, the best …