The present review summarizes recent publications devoted to aminoglycosides that study
the main types of resistance to antibiotics of this class and the main directions of chemical …

The conjugation of hydrophobic group (s) to the polycationic hydrophilic core of the antibiotic
drugs aminoglycosides (AGs), targeting ribosomal RNA, has led to the development of …

In our body, all the cells are constantly sharing chemical and electrical information with other
cells. This intercellular communication allows them to respond in a concerted way to …

Widely-used Streptomyces-derived antibacterial aminoglycosides have encountered
challenges because of antibiotic resistance and toxicity. Today, they are largely relegated to …

Connexins are membrane proteins involved directly in cell-to-cell communication through
the formation of gap-junctional channels. These channels result from the head-to-head …

Amphiphilic aminoglycosides have attracted interest due to their novel antifungal activities. A
crucial but often neglected factor for drug development in academia is cost of production …

Connexin hemichannels (HCs) expressed at the plasma membrane of mammalian cells are
of paramount importance for intercellular communication. In physiological conditions, HCs …

Gap junction channels formed by the association of connexin hemichannels play a crucial
role in intercellular communication. Connexin 43 (Cx43) is expressed in a variety of tissues …

Amphiphilic kanamycins derived from the classic antibiotic kanamycin have attracted interest
due to their novel bioactivities beyond inhibition of bacteria. In this study, the recently …

Gap-junction channels formed by two connexin hemichannels play diverse and pivotal roles
in intercellular communication and regulation. Normally hemichannels at the plasma …