γδ T-cells directly recognize and kill transformed cells independently of HLA-antigen
presentation, which makes them a highly promising effector cell compartment for cancer …

Although the phosphorus atom is found in a variety of oxidation states, most of the
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …

Abstract β-Elemene is a valuable sesquiterpene isolated from the essential oil of the
traditional Chinese medicine Curcuma wenyujin. As a Chinese class II non-cytotoxic …

Dioscorea zingiberensis is a major pharmaceutical plant that produces diosgenin, an
important starting material for steroidal hormones. To date, no genome editing approach in …

Farnesyl diphosphate synthase (FDPS), a mevalonate pathway enzyme, is highly expressed
in several cancers, including prostate cancer (PCa). To date, the mechanistic, functional …

Predicting phenotype from genotype represents the epitome of biological questions.
Comparative genomics of appropriate model organisms holds the promise of making it …

Plants are major factories for the biosynthesis of valuable bioactive compounds having
pharmaceutical applications. These phytocompounds are synthesised via the diversion of …

Cholesterol biosynthesis serves as a central metabolic hub for numerous biological
processes in health and disease. A detailed, integrative single-view description of how the …

Never before have we had the luxury of choosing a continent, picking a large phylogenetic
group of animals, and obtaining genomic data for its every species. Here, we sequence all …

Dendrobium nobile Lindl. has been used as a traditional Chinese medicine for a long time,
in which the most important compound is dendrobine functioning in a variety of …