Recent evidence enriches our understanding of the molecular sites of action of cocaine
reward and locomotor stimulation. Dopamine transporter blockade by cocaine appears a …

Genetic studies of substance abuse indicate that variation in the risk for the disorder in the
population is contributed by differences in both individual genotypes and environment …

A human μ opiate receptor cDNA has been identified from a cerebral cortical cDNA library
using sequences from the rat μ opiate receptor cDNA. The human μ opiate receptor (hμOR1) …

A polymorphism involving a variable number of tandem repeats (VNTR) has been described
in the 3′ untranslated region of the gene (SLC6A3) coding for the dopamine transporter …

Polymorphisms of three different dopaminergic genes, dopamine D2 receptor (DRD2),
dopamine β‐hydroxylase (DβH), and dopamine transporter (DAT1), were examined in …

Dopamine transporter (DAT) levels vary in normal subjects and deviate from the normal
range in pathological states. We investigated mechanisms by which the DAT gene may …

Background: The dopamine transporter (DAT) is the primary mechanism for dopamine
clearance from the synapse in midbrain dopaminergic neurons, and the target of …

Allelic variants at the catechol‐O‐methyl‐transferase (COMT) locus are candidates to
contribute to genetic components of interindividual differences in vulnerability to substance …

Paranoia in the context of cocaine abuse is common and potentially dangerous. Several
lines of evidence suggest that this phenomenon may be related to function of the dopamine …

Hereditary factors confer susceptibility to alcohol dependence. Alcohol mediates its
reinforcing effects by enhancing dopamine activity in the mesolimbic dopamine system. The …