Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …

Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

A fundamental question in bone biology concerns the contributions of skeletal
stem/progenitor cells (SSCs) in the bone marrow versus the periosteum to bone repair. We …

An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …

Mesenchymal stem cells (MSCs) are multilineage cells with the ability to self-renew and
differentiate into a variety of cell types, which play key roles in tissue healing and …

Osteoarthritis (OA) is a degenerative disease resulting in irreversible, progressive
destruction of articular cartilage. The etiology of OA is complex and involves a variety of …

The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

Haematological malignancies were previously thought to be driven solely by genetic or
epigenetic lesions within haematopoietic cells. However, the niches that maintain and …

It was shown as long as half a century ago that bone marrow is a source of not only
hematopoietic stem cells, but also stem cells of mesenchymal tissues. Then the term …