Recent development of innovative tools for live imaging of actin filaments (F-actin) enabled
the detection of surprising nuclear structures responding to various stimuli, challenging …

A number of studies across different model systems revealed that chromatin undergoes
significant changes in dynamics in response to DNA damage. These include local motion …

The actin cytoskeleton is of fundamental importance for numerous cellular processes,
including intracellular transport, cell plasticity, and cell migration. However, functions of …

Highlights•Nuclear actin filaments and myosins drive the directed motions of
heterochromatic repair sites.•Local and global changes in heterochromatin dynamics …

In response to DNA double-strand breaks (DSBs), chromatin modifications orchestrate DNA
repair pathways thus safeguarding genome integrity. Recent studies have uncovered a key …

DNA double-strand breaks (DSBs) are particularly challenging to repair in pericentromeric
heterochromatin because of the increased risk of aberrant recombination in highly repetitive …

Cycling cells must respond to DNA double-strand breaks (DSBs) to avoid genome instability.
Missegregation of chromosomes with DSBs during mitosis results in micronuclei, aberrant …

Actin is a highly conserved protein in mammals. The actin dynamics is regulated by actin-
binding proteins and actin-related proteins. Nuclear actin and these regulatory proteins …

Pericentromeric heterochromatin is mostly composed of repetitive DNA sequences prone to
aberrant recombination. Cells have developed highly specialized mechanisms to enable …

Pericentromeric heterochromatin is highly enriched for repetitive sequences prone to
aberrant recombination. Previous studies showed that homologous recombination (HR) …