Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA,
insufficient availability of charged tRNAs and genetic errors. All organisms have evolved …

Linkers play critical roles in the construction of synthetic protein switches and sensors as
they functionally couple a receptor with an actuator. With an increasing number of molecular …

Tandemly repeated DNA is highly mutable and causes at least 31 diseases, but it is hard to
detect pathogenic repeat expansions genome-wide. Here, we report robust detection of …

Repeat-associated non-AUG (RAN) translation produces toxic polypeptides from nucleotide
repeat expansions in the absence of an AUG start codon and contributes to …

Trinucleotide repeats (TNRs) are of interest in genetics because they are used as markers
for tracing genotype–phenotype relations and because they are directly involved in …

Proteins containing glutamine repeats (polyQ) are known to be structurally unstable.
Abnormal expansion of polyQ in some proteins exceeding a certain threshold leads to …

A wide variety of oligomeric structures are formed during the aggregation of proteins
associated with neurodegenerative diseases. Such soluble oligomers are believed to be key …

Trinucleotide repeat (TNR) expansions are present in a wide range of genes involved in
several neurological disorders, being directly involved in the molecular mechanisms …

The expansion of homopolymeric glutamine (polyQ) or alanine (polyA) repeats in certain
proteins owing to genetic mutations induces protein aggregation and toxicity, causing at …

The Ribosome-associated Quality Control (RQC) pathway co-translationally marks
incomplete polypeptides from stalled translation with two signals that trigger their …