Artificial intelligence in early drug discovery enabling precision medicine
Introduction: Precision medicine is the concept of treating diseases based on environmental
factors, lifestyles, and molecular profiles of patients. This approach has been found to …
factors, lifestyles, and molecular profiles of patients. This approach has been found to …
Immunoinformatics and epitope prediction in the age of genomic medicine
L Backert, O Kohlbacher - Genome medicine, 2015 - Springer
Immunoinformatics involves the application of computational methods to immunological
problems. Prediction of B-and T-cell epitopes has long been the focus of immunoinformatics …
problems. Prediction of B-and T-cell epitopes has long been the focus of immunoinformatics …
Major histocompatibility complex class I binding predictions as a tool in epitope discovery
Over the last decade, in silico models of the major histocompatibility complex (MHC) class I
pathway have developed significantly. Before, peptide binding could only be reliably …
pathway have developed significantly. Before, peptide binding could only be reliably …
State of the art and challenges in sequence based T-cell epitope prediction
Sequence based T-cell epitope predictions have improved immensely in the last decade.
From predictions of peptide binding to major histocompatibility complex molecules with …
From predictions of peptide binding to major histocompatibility complex molecules with …
POPISK: T-cell reactivity prediction using support vector machines and string kernels
Background Accurate prediction of peptide immunogenicity and characterization of relation
between peptide sequences and peptide immunogenicity will be greatly helpful for vaccine …
between peptide sequences and peptide immunogenicity will be greatly helpful for vaccine …
Designing string-of-beads vaccines with optimal spacers
B Schubert, O Kohlbacher - Genome medicine, 2016 - Springer
String-of-beads polypeptides allow convenient delivery of epitope-based vaccines. The
success of a polypeptide relies on efficient processing: constituent epitopes need to be …
success of a polypeptide relies on efficient processing: constituent epitopes need to be …
Signal peptides and trans-membrane regions are broadly immunogenic and have high CD8+ T cell epitope densities: Implications for vaccine development
R Kovjazin, I Volovitz, Y Daon, T Vider-Shalit… - Molecular …, 2011 - Elsevier
Cell mediated immune response has a major role in controlling the elimination of infectious
agents. The rational design of sub-unit peptide vaccines against intracellular pathogens or …
agents. The rational design of sub-unit peptide vaccines against intracellular pathogens or …
Computer‐aided design of T‐cell epitope‐based vaccines: addressing population coverage
Epitope‐based vaccines (EV s) make use of short antigen‐derived peptides corresponding
to immune epitopes, which are administered to trigger a protective humoral and/or cellular …
to immune epitopes, which are administered to trigger a protective humoral and/or cellular …
Universal peptide vaccines–optimal peptide vaccine design based on viral sequence conservation
Rapidly mutating viruses such as the hepatitis C virus (HCV), the human immunodeficiency
virus (HIV), or influenza viruses (Flu) call for highly effective universal peptide vaccines, ie …
virus (HIV), or influenza viruses (Flu) call for highly effective universal peptide vaccines, ie …
Models of RNA virus evolution and their roles in vaccine design
S Ojosnegros, N Beerenwinkel - Immunome research, 2010 - Springer
Viruses are fast evolving pathogens that continuously adapt to the highly variable
environments they live and reproduce in. Strategies devoted to inhibit virus replication and …
environments they live and reproduce in. Strategies devoted to inhibit virus replication and …