Obesity is a pathophysiological state defined by a body mass index> 30 kg/m 2 and
characterized by an adipose tissue accumulation leading to an important weight increased …

The risk of malignant tumor development is increasing in the world. Obesity is an
established risk factor for various malignancies. There are many metabolic alterations …

Polypharmacy is common in patients with nonalcoholic fatty liver disease (NAFLD) and
previous reports suggest that NAFLD is associated with altered drug disposition. This study …

Gene-environment interaction studies are emerging as a promising tool to shed light on the
reasons for the rapid increase in excess body weight (overweight and obesity). We aimed to …

Background: Changes in the gastrointestinal physiology after bariatric surgery may affect the
pharmacokinetics of medications. Data on the impact of different surgical techniques on the …

Obesity and underweight are a growing health problem worldwide and a challenge for
clinicians concerning antithrombotic therapy, due to the associated risks of thrombosis …

Roux-en-Y gastric bypass (RYGB) involves creating a small stomach pouch, bypassing part
of the small intestine, and rerouting the digestive tract. These alterations can potentially …

Obesity and underweight are a growing health problem worldwide and a challenge for
clinicians concerning antithrombotic therapy, due to the associated risks of thrombosis …

Abstract Background and Objective Several drugs on the market are substrates for P-
glycoprotein (P-gp), an efflux transporter highly expressed in barrier tissues such as the …

This study employed physiologically‐based pharmacokinetic–pharmacodynamics
(PBPK/PD) modeling to predict the effect of obesity and gastric bypass surgery on the …