Mechanisms and clinical implications of intervertebral disc calcification
Low back pain is a leading cause of disability worldwide. Intervertebral disc (IVD)
degeneration is often associated with low back pain but is sometimes asymptomatic. IVD …
degeneration is often associated with low back pain but is sometimes asymptomatic. IVD …
Discogenic back pain: literature review of definition, diagnosis, and treatment
K Fujii, M Yamazaki, JD Kang… - Journal of Bone and …, 2019 - academic.oup.com
Discogenic back pain is multifactorial; hence, physicians often struggle to identify the
underlying source of the pain. As a result, discogenic back pain is often hard to treat—even …
underlying source of the pain. As a result, discogenic back pain is often hard to treat—even …
Biomaterials for intervertebral disc regeneration: Current status and looming challenges
A biomaterial‐based strategy is employed to regenerate the degenerated intervertebral disc,
which is considered a major generator of neck and back pain. Although encouraging …
which is considered a major generator of neck and back pain. Although encouraging …
Development of a standardized histopathology scoring system for human intervertebral disc degeneration: an Orthopaedic Research Society Spine Section Initiative
Background Histopathological analysis of intervertebral disc (IVD) tissues is a critical
domain of back pain research. Identification, description, and classification of attributes that …
domain of back pain research. Identification, description, and classification of attributes that …
Modic changes-An evidence-based, narrative review on its patho-physiology, clinical significance and role in chronic low back pain
VK Viswanathan, AP Shetty, S Rajasekaran - Journal of clinical …, 2020 - Elsevier
Objective Lumbar degenerative spinal ailments are the most important causes for chronic
low back pain. Modic changes (MC) are vertebral bone marrow signal intensity changes …
low back pain. Modic changes (MC) are vertebral bone marrow signal intensity changes …
Imaging in spine surgery: current concepts and future directions
Objective: To review and highlight the historical and recent advances of imaging in spine
surgery and to discuss current applications and future directions. Methods: A PubMed …
surgery and to discuss current applications and future directions. Methods: A PubMed …
Multidimensional vertebral endplate defects are associated with disc degeneration, modic changes, facet joint abnormalities, and pain
U Zehra, JPY Cheung, C Bow, W Lu… - Journal of …, 2019 - Wiley Online Library
The aim of the current study was to investigate the multi‐dimensional characteristics of
lumbar endplate defects in humans in relation to disc degeneration and other MRI …
lumbar endplate defects in humans in relation to disc degeneration and other MRI …
Biomarkers for intervertebral disc and associated back pain: From diagnosis to disease prognosis and personalized treatment
Biomarkers are commonly recognized as objective indicators of a medical state or clinical
outcome and have been widely used as clinical and diagnostic tools and surrogate …
outcome and have been widely used as clinical and diagnostic tools and surrogate …
Spinopelvic alignment predicts disc calcification, displacement, and Modic changes: evidence of an evolutionary etiology for clinically‐relevant spinal phenotypes
U Zehra, JPY Cheung, C Bow, RJ Crawford… - JOR …, 2020 - Wiley Online Library
Lumbar disc‐displacement, Modic changes (MCs), and UTE Disc Sign (UDS) on MRI are
clinically relevant spinal phenotypes that can lead to sciatica/LBP. Not all degenerated discs …
clinically relevant spinal phenotypes that can lead to sciatica/LBP. Not all degenerated discs …
[HTML][HTML] Biomarkers for intervertebral disc and associated back pain: From diagnosis to disease prognosis and personalized treatment
CL Pereira, S Grad, RM Gonçalves - JOR spine, 2023 - ncbi.nlm.nih.gov
Biomarkers are commonly recognized as objective indicators of a medical state or clinical
outcome and have been widely used as clinical and diagnostic tools and surrogate …
outcome and have been widely used as clinical and diagnostic tools and surrogate …