A healthy aorta exerts a powerful cushioning function, which limits arterial pulsatility and
protects the microvasculature from potentially harmful fluctuations in pressure and blood …

Background Reduced cerebral blood flow (CBF) contributes to the pathophysiology of
Alzheimer's disease (AD). However, it is unclear whether there is a spatial-temporal-specific …

Mild cognitive impairment (MCI), a condition characterizing poor cognition, is associated
with aging and depicts early symptoms of severe cognitive impairment, known as …

Blood flow metrics obtained with four-dimensional (4D) flow phase contrast (PC) magnetic
resonance imaging (MRI) can be of great value in clinical and experimental cerebrovascular …

Reduced middle cerebral artery blood velocity (MCAv) and flow pulsatility are contributors to
age-related cerebrovascular disease pathogenesis. It is unknown whether the rate of …

The vascular hypothesis of Alzheimer's disease (VHAD) was proposed 24 years ago from
observations made in our laboratory using aging rats subjected to chronic brain …

This mini-review is aimed at briefly summarizing the present status of functional near-
infrared spectroscopy (fNIRS) and predicting where the technique should go in the next …

Intact, coordinated, and precisely regulated cerebrovascular responses are required for the
maintenance of cerebral metabolic homeostasis, adequate perfusion, oxygen delivery, and …

Background and Purpose—Cerebral small vessel disease (SVD) is a major cause of stroke
and dementia, but underlying disease mechanisms are still largely unknown, partly because …

Hypoxia is a state of reduced oxygen supply and excessive oxygen consumption. According
to the duration of hypoxic period, it can be classified as acute and chronic hypoxia. Both …