The senescence-associated secretory phenotype (SASP) defines the ability of senescent
cells to express and secrete a variety of extracellular modulators that includes cytokines …

Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation
affecting predominantly the lung parenchyma and peripheral airways that results in largely …

Cellular senescence, an integral component of aging and cancer, arises in response to
diverse triggers, including telomere attrition, macromolecular damage and signaling from …

The signaling networks that drive the aging process, associated functional deterioration, and
pathologies has captured the scientific community's attention for decades. While many …

Chronic obstructive pulmonary disease (COPD) is a major global health problem that is
poorly treated by current therapies as it has proved difficult to treat the underlying …

The central functions fulfilled by mitochondria as both energy generators essential for tissue
homeostasis and gateways to programmed apoptotic and necrotic cell death mandate tight …

SARS‐CoV‐2 is a novel betacoronavirus which infects the lower respiratory tract and can
cause coronavirus disease 2019 (COVID‐19), a complex respiratory distress syndrome …

Mitochondria are biosynthetic, bioenergetic, and signaling organelles which are critical for
physiological adaptations and cellular stress responses to the environment. Various …

Extracellular vesicles (EVs) play a vital role in normal lung physiology to maintain
homeostasis in the airways via intercellular communication. EVs include exosomes and …

Aging is a major risk factor for the development of chronic lung diseases such as chronic
obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer …