The multiplex model of the genetics of Alzheimer's disease
Genes play a strong role in Alzheimer's disease (AD), with late-onset AD showing heritability
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
of 58–79% and early-onset AD showing over 90%. Genetic association provides a robust …
Alzheimer's disease: a matter of blood–brain barrier dysfunction?
The blood–brain barrier (BBB) keeps neurotoxic plasma-derived components, cells, and
pathogens out of the brain. An early BBB breakdown and/or dysfunction have been shown in …
pathogens out of the brain. An early BBB breakdown and/or dysfunction have been shown in …
A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders
We describe a human single-nuclei transcriptomic atlas for the substantia nigra (SN),
generated by sequencing approximately 17,000 nuclei from matched cortical and SN …
generated by sequencing approximately 17,000 nuclei from matched cortical and SN …
ApoE4: an emerging therapeutic target for Alzheimer's disease
M Safieh, AD Korczyn, DM Michaelson - BMC medicine, 2019 - Springer
Background The growing body of evidence indicating the heterogeneity of Alzheimer's
disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy …
disease (AD), coupled with disappointing clinical studies directed at a fit-for-all therapy …
Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease
AD Marais - Pathology, 2019 - Elsevier
Summary Apolipoprotein E (apoE), a 34 kDa circulating glycoprotein of 299 amino acids,
predominantly synthesised in the liver, associates with triglyceride-rich lipoproteins to …
predominantly synthesised in the liver, associates with triglyceride-rich lipoproteins to …
Metabolic network analysis reveals altered bile acid synthesis and metabolism in Alzheimer's disease
Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by
primary and secondary bile acids, the end product of cholesterol metabolism. We analyze …
primary and secondary bile acids, the end product of cholesterol metabolism. We analyze …
Metabolic dysregulation contributes to the progression of Alzheimer's disease
X Yan, Y Hu, B Wang, S Wang, X Zhang - Frontiers in neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …
APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function
M Xiong, H Jiang, JR Serrano, ER Gonzales… - Science translational …, 2021 - science.org
The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-
onset Alzheimer's disease (AD) and greatly influences the development of amyloid-β (Aβ) …
onset Alzheimer's disease (AD) and greatly influences the development of amyloid-β (Aβ) …
Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism
Background Clearance at the blood-brain barrier (BBB) plays an important role in removal of
Alzheimer's amyloid-β (Aβ) toxin from brain both in humans and animal models …
Alzheimer's amyloid-β (Aβ) toxin from brain both in humans and animal models …
Astrocytes as a therapeutic target in alzheimer's disease–comprehensive review and recent developments
M Rodríguez-Giraldo, RE González-Reyes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a frequent and disabling neurodegenerative disorder, in which
astrocytes participate in several pathophysiological processes including neuroinflammation …
astrocytes participate in several pathophysiological processes including neuroinflammation …