The blood-brain barrier (BBB) is a dynamic structure that functions as a gatekeeper,
reflecting the unique requirements of the brain. In this review, following a brief historical …

The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …

Blood–brain/blood–tumor barriers (BBB and BTB) and interstitial transport may constitute
major obstacles to the transport of therapeutics in brain tumors. In this study, we examined …

Simple Summary Glioblastoma (GBM) is a common primary brain tumor with a short median
overall survival despite aggressive treatment with resection, chemotherapy, and radiation …

The delivery of systemically administered gene therapies to brain tumors is exceptionally
difficult because of the blood-brain barrier (BBB) and blood-tumor barrier (BTB). In addition …

Introduction: Ultrasound in combination with microbubbles can make cells and tissues more
accessible for drugs, thereby achieving improved therapeutic outcomes. In this review, we …

Brain tumors are characterized by very high mortality and, despite the continuous research
on new pharmacological interventions, little therapeutic progress has been made. One of the …

Immunotherapy is rapidly emerging as the cornerstone for the treatment of several forms of
metastatic cancer, as well as for a host of other pathologies. Meanwhile, several new high …

Effective drug delivery in brain tumors remains a major challenge in oncology. Although
local hyperthermia and stimuli-responsive delivery systems, such as thermosensitive …

Therapeutic ultrasound is only beginning to be applied to neurologic conditions, but the
potential of this modality for a wide spectrum of brain applications is high. Engineering …