Myotonic dystrophy type I (DM1) is the most common form of adult muscular dystrophy,
caused by expansion of a CTG triplet repeat in the 3′ untranslated region (3′ UTR) of the …

Muscleblind-like (MBNL) proteins are key regulators of precursor and mature mRNA
metabolism in mammals. Based on published and novel data, we explore models of tissue …

Specific protein-RNA interactions guide posttranscriptional gene regulation. Here, we
describe RNA Bind-n-Seq (RBNS), a method that comprehensively characterizes sequence …

CUGBP1 and MBNL1 are developmentally regulated RNA-binding proteins that are causally
associated with myotonic dystrophy type 1. We globally determined the in vivo RNA-binding …

Abstract Cys2His2 (C2H2)-type zinc fingers are widespread DNA binding motifs in
eukaryotic transcription factors. Zinc fingers are short protein motifs composed of two or …

Short tandem repeat (STR) or microsatellite, expansions underlie more than 50 hereditary
neurological, neuromuscular and other diseases, including myotonic dystrophy types 1 …

Myotonic dystrophy type 1 is caused by abnormal expansion of a CTG-trinucleotide repeat in
the gene encoding Dystrophia Myotonica Protein Kinase (DMPK), which in turn leads to …

Short Tandem Repeats (STRs) are frequent entities in many transcripts, however, in some
cases, pathological events occur when a critical repeat length is reached. This phenomenon …

RNA-binding proteins (RBPs) impact every process in the cell; they act as splicing and
polyadenylation factors, transport and localization factors, stabilizers and destabilizers …

Abstract Myotonic Dystrophy type I (DM1) is caused by an abnormal expansion of CTG
triplets in the 3′ UTR of the dystrophia myotonica protein kinase (DMPK) gene, leading to …