Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery
Design and functionalization strategies for multifunctional nanocarriers (eg, nanoparticles,
micelles, polymersomes) based on biodegradable/biocompatible polymers intended to be …
micelles, polymersomes) based on biodegradable/biocompatible polymers intended to be …
Delivery of therapeutics to the inner ear: The challenge of the blood-labyrinth barrier
S Nyberg, NJ Abbott, X Shi, PS Steyger… - Science translational …, 2019 - science.org
Permanent hearing loss affects more than 5% of the world's population, yet there are no
nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the …
nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the …
Advances and future perspectives in epithelial drug delivery
Epithelial surfaces protect exposed tissues in the body against intrusion of foreign materials,
including xenobiotics, pollen and microbiota. The relative permeability of the various …
including xenobiotics, pollen and microbiota. The relative permeability of the various …
Recent advances in local drug delivery to the inner ear
Inner ear diseases are not adequately treated by systemic drug administration mainly
because of the blood–perilymph barrier that reduces exchanges between plasma and inner …
because of the blood–perilymph barrier that reduces exchanges between plasma and inner …
Gold‐nanorod‐assisted near‐infrared stimulation of primary auditory neurons
Infrared stimulation offers an alternative to electrical stimulation of neuronal tissue, with
potential for direct, non‐contact activation at high spatial resolution. Conventional methods …
potential for direct, non‐contact activation at high spatial resolution. Conventional methods …
Drug delivery across barriers to the middle and inner ear
The prevalence of ear disorders has spurred efforts to develop drug delivery systems to treat
these conditions. Here, recent advances in drug delivery systems that access the ear …
these conditions. Here, recent advances in drug delivery systems that access the ear …
New molecular therapies for the treatment of hearing loss
An estimated 466 million people suffer from hearing loss worldwide. Sensorineural hearing
loss is characterized by degeneration of key structures of the sensory pathway in the …
loss is characterized by degeneration of key structures of the sensory pathway in the …
From molecular to nanotechnology strategies for delivery of neurotrophins: emphasis on brain-derived neurotrophic factor (BDNF)
C Géral, A Angelova, S Lesieur - Pharmaceutics, 2013 - mdpi.com
Neurodegenerative diseases represent a major public health problem, but beneficial clinical
treatment with neurotrophic factors has not been established yet. The therapeutic use of …
treatment with neurotrophic factors has not been established yet. The therapeutic use of …
Gene therapy for human sensorineural hearing loss
Hearing loss is the most common sensory impairment in humans and currently disables 466
million people across the world. Congenital deafness affects at least 1 in 500 newborns, and …
million people across the world. Congenital deafness affects at least 1 in 500 newborns, and …
Advances in nano-based inner ear delivery systems for the treatment of sensorineural hearing loss
L Li, T Chao, J Brant, B O'Malley Jr, A Tsourkas… - Advanced drug delivery …, 2017 - Elsevier
Sensorineural hearing loss (SNHL) is one of the most common diseases, accounting for
about 90% of all hearing loss. Leading causes of SNHL include advanced age, ototoxic …
about 90% of all hearing loss. Leading causes of SNHL include advanced age, ototoxic …