It has been thought that caloric restriction favors longevity and healthy aging where
autophagy plays a vital role. However, autophagy decreases during aging and that can lead …

A hallmark of Alzheimer's disease (AD) are the proteinaceous aggregates formed by the
amyloid-beta peptide (Aβ) that is deposited inside the brain as amyloid plaques. The …

Drug development for the treatment of Alzheimer's disease (AD) has been for a long time
focused on agents that were expected to support endogenous β-amyloid (Aβ) in a …

Cholinergic dysfunction in Alzheimer's disease (AD) can be mediated by the neuronal α7
nicotinic acetylcholine receptor (α7nAChR). Beta-amyloid peptide (Aβ) binds to the …

About half of the globular proteins are composed of regular secondary structures, α-helices,
and β-sheets, while the rest are constituted of irregular secondary structures, such as turns …

Advances in the research of molecular factors involved in the onset and progression of
Alzheimer's disease, have led to the creation of several pathogenesis concepts of the most …

The biofilms of Enterobacteriaceae are fortified by assembly of curli amyloid fibres on the
cell surface. Curli not only provides structural reinforcement, but also facilitates surface …

Alzheimer's disease (AD) is a neurodegenerative disease accompanied by progressive
cognitive and memory dysfunction due to disruption of normal electrotonic properties of …

The cholinergic deficit in Alzheimer's disease (AD) may arise from selective loss of
cholinergic neurons caused by the binding of Aβ peptide to nicotinic acetylcholine receptors …

Predicting the polyproline type II (PPII) helix structure is crucial important in many research
areas, such as the protein folding mechanisms, the drug targets, and the protein functions …