INTRODUCTION Currently there are no approved treatments for sarcopenia, the age-
dependent loss of skeletal muscle mass and strength that constitutes a major public health …

Quiescence regulation is essential for adult stem cell maintenance and sustained
regeneration. Our studies uncovered that physiological changes in mitochondrial shape …

Research on age-related regenerative failure of skeletal muscle has extensively focused on
the phenotypes of muscle stem cells (MuSCs). In contrast, the impact of aging on regulatory …

Skeletal muscle accounts for almost 40% of the total adult human body mass. This tissue is
essential for structural and mechanical functions such as posture, locomotion, and …

Satellite cells are required for the growth, maintenance, and regeneration of skeletal muscle.
Quiescent satellite cells possess a primary cilium, a structure that regulates the processing …

During aging, the regenerative capacity of muscle stem cells (MuSCs) decreases,
diminishing the ability of muscle to repair following injury. We found that the ability of MuSCs …

Lack of dystrophin causes muscle degeneration, which is exacerbated by chronic
inflammation and reduced regenerative capacity of muscle stem cells in Duchenne Muscular …

Muscle stem cell function has been suggested to be regulated by Acetyl-CoA and NAD+
availability, but the mechanisms remain unclear. Here we report the identification of two …

ABSTRACT Purpose/Aim: Skeletal muscle tissue explants have been cultured and studied
for nearly 100 years. These cultures, which retain complex tissue structure in an …

Muscle stem cells (MuSCs) experience age-associated declines in number and function,
accompanied by mitochondrial electron transport chain (ETC) dysfunction and increased …