Diabetes mellitus is a metabolic disorder that majorly affects the endocrine gland, and it is
symbolized by hyperglycemia and glucose intolerance owing to deficient insulin secretory …

Type 2 diabetes (T2D) and obesity are relevant worldwide chronic diseases. A common
complication in both pathologies is the dysregulation of the insulin-signaling pathway that is …

Background & aims The beneficial effect of genistein has indicated on metabolic disorders
and inflammatory state. The aim of this study was to investigate the effect of genistein …

Articular cartilage degeneration is hallmark of osteoarthritis (OA). Low-grade chronic
inflammation in the joint can promote OA progression. Emerging evidence indicates that …

NAFLD is a vital health problem worldwide; however, no effective treatment is currently
available for NAFLD. Intensive studies have indicated the efficacy of genistein (GE), a …

In recent years, there is emerging evidence that isoflavonoids, either dietary or obtained
from traditional medicinal plants, could play an important role as a supplementary drug in …

Daidzein shows estrogenic, antioxidant and antiandrogenic properties as well as cell cycle
regulatory activity. However, the antihyperglycemic effect of daidzein remains to be …

AMPK is a serine/threonine protein kinase that has the function of maintaining the balance
between ATP production and consumption in most eukaryotic cells. It plays a relevant role in …

Meretrix lusoria (M. lusoria) is an economically important shellfish which is widely distributed
in South Eastern Asia that contains bioactive peptides, proteins, and enzymes. In the present …

Obesity presents a major health challenge that increases the risk of several non-
communicable illnesses, such as but not limited to diabetes, hypertension, cardiovascular …