Janus kinase inhibitors in the treatment of vitiligo: a review

F Qi, F Liu, L Gao - Frontiers in immunology, 2021 - frontiersin.org
Vitiligo is a multifactorial reversible skin disorder characterized by distinct white patches that
result from melanocyte destruction. Activated CXCR3+ CD8+ T cells promote melanocyte …

Vitiligo: mechanisms of pathogenesis and treatment

ML Frisoli, K Essien, JE Harris - Annual review of immunology, 2020 - annualreviews.org
Vitiligo is an autoimmune disease of the skin that targets pigment-producing melanocytes
and results in patches of depigmentation that are visible as white spots. Recent research …

Targeting the Janus kinase family in autoimmune skin diseases

MD Howell, FI Kuo, PA Smith - Frontiers in immunology, 2019 - frontiersin.org
Autoimmune skin diseases are characterized by significant local and systemic inflammation
that is largely mediated by the Janus kinase (JAK)–signal transducer and activator of …

scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in Treg function

KJ Gellatly, JP Strassner, K Essien, MA Refat… - Science translational …, 2021 - science.org
Vitiligo is an autoimmune skin disease characterized by the targeted destruction of
melanocytes by T cells. Cytokine signaling between keratinocytes and T cells results in …

Ruxolitinib cream for treatment of vitiligo: a randomised, controlled, phase 2 trial

D Rosmarin, AG Pandya, M Lebwohl, P Grimes… - The Lancet, 2020 - thelancet.com
Background Vitiligo is a chronic autoimmune disease resulting in skin depigmentation and
reduced quality of life. There is no approved treatment for vitiligo repigmentation and current …

Vitiligo, from pathogenesis to therapeutic advances: state of the art

F Diotallevi, H Gioacchini, E De Simoni… - International Journal of …, 2023 - mdpi.com
Vitiligo is an acquired hypopigmentation of the skin due to a progressive selective loss of
melanocytes; it has a prevalence of 1–2% and appears as rounded, well-demarcated white …

Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo

JM Richmond, JP Strassner, L Zapata Jr… - Science translational …, 2018 - science.org
Vitiligo is an autoimmune disease of the skin mediated by CD8+ T cells that kill melanocytes
and create white spots. Skin lesions in vitiligo frequently return after discontinuing …

[HTML][HTML] Vitiligo skin is imprinted with resident memory CD8 T cells expressing CXCR3

K Boniface, C Jacquemin, AS Darrigade… - Journal of Investigative …, 2018 - Elsevier
Vitiligo is a chronic autoimmune depigmenting skin disorder that results from a loss of
melanocytes. Multiple combinatorial factors have been involved in disease development …

Repigmentation in vitiligo using the Janus kinase inhibitor tofacitinib may require concomitant light exposure

LY Liu, JP Strassner, MA Refat, JE Harris… - Journal of the American …, 2017 - Elsevier
Background Vitiligo is an autoimmune disease in which cutaneous depigmentation occurs.
Existing therapies are often inadequate. Prior reports have shown benefit of the Janus …

Clinical features, immunopathogenesis, and therapeutic strategies in vitiligo

Y Wang, S Li, C Li - Clinical Reviews in Allergy & Immunology, 2021 - Springer
Vitiligo is an autoimmune disease of the skin characterized by epidermal melanocyte loss
resulting in white patches, with an approximate prevalence of 0.5–2% worldwide. Several …