Amino acid mutations that lower a protein's thermodynamic stability are implicated in
numerous diseases, and engineered proteins with enhanced stability can be important in …

Peptidyl-tRNA hydrolase 2 (PTRH2) is an evolutionarily highly conserved mitochondrial
protein. The biallelic mutations in the PTRH2 gene have been suggested to cause a rare …

Febrile seizures (FS) are the most common form of epilepsy in children between six months
and five years of age. FS is a self-limited type of fever-related seizure. However, complicated …

The mono (2-hydroxyethyl) terephthalate hydrolase (MHETase) from Ideonella sakaiensis
carries out the second step in the enzymatic depolymerization of poly (ethylene …

Thermal stability of proteins is a primary metric for evaluating their physical properties.
Although researchers attempted to predict it using machine learning frameworks, their …

There is strong interest in accurate methods for predicting changes in protein stability
resulting from amino acid mutations to the protein sequence. Recombinant proteins must …

Numerous high-specificity Cas9 variants have been engineered for precision genome
editing. These variants typically harbor multiple mutations designed to alter the Cas9-single …

Numerous high-specificity Cas9 variants have been engineered for precision genome
editing. These variants typically harbor multiple mutations designed to alter the Cas9-single …

Heterotrimeric G proteins (Gα, Gβ and Gγ) act downstream of G-protein-coupled receptors
(GPCRs) to mediate signaling pathways that regulate various physiological processes and …

Peptidyl-tRNA hydrolase 2 (PTRH2) is an evolutionarily highly conserved mitochondrial
protein. The biallelic mutations in the PTRH2 gene have been suggested to cause a rare …