Chromones are a group of naturally occurring compounds that are ubiquitous in nature,
especially in plants. The word chromone is derived from the Greek word chroma, meaning …

This review aims to be a comprehensive, authoritative, critical, and readable review of
general interest to the medicinal chemistry community because it focuses on the …

Accumulating evidence shows a relationship between the human MAO-B (hMAO-B) enzyme
and neuropsychiatric/degenerative disorder, personality traits, type II alcoholism, borderline …

Monoamine oxidase is a flavin enzyme that catalyzes the oxidation of monoamine
neurotransmitters in the brain. Various toxic by-products, aldehydes and hydrogen peroxide …

Monoamine oxidase (MAO) enzyme catalyzes the oxidative deamination of xenobiotic and
endogenous amines including many neurotransmitters. The MAO enzyme exists in two …

Chromones are the class of secondary metabolites that broadly occur in the plant kingdom
in a noticeable quantity. This rigid bicyclic system has been categorized “as privileged …

Two series of novel chromone derivatives were synthesized and investigated for their ability
to inhibit the activity of monoamine oxidase. The SAR data indicate that chromone …

The discovery of new chemical entities endowed with potent, selective, and reversible
monoamine oxidase B inhibitory activity is a clinically relevant subject. Therefore, a small …

Abstract Series of 4H-chromen-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylate derivatives 7a–
7zb, 8a–8d and 9a–9d were synthesized and screened for their in vitro anti-mycobacterial …

There has been a substantial research effort to design multi-target ligands for the treatment
of Alzheimer's disease (AD), an approach that is moved by the knowledge that AD is a …