Dialog beyond the grave: necrosis in the tumor microenvironment and its contribution to tumor growth

E Zapletal, T Vasiljevic, P Busson… - International journal of …, 2023 - mdpi.com
Damage-associated molecular patterns (DAMPs) are endogenous molecules released from
the necrotic cells dying after exposure to various stressors. After binding to their receptors …

Heat shock protein 90: biological functions, diseases, and therapeutic targets

H Wei, Y Zhang, Y Jia, X Chen, T Niu, A Chatterjee… - MedComm, 2024 - Wiley Online Library
Abstract Heat shock protein 90 (Hsp90) is a predominant member among Heat shock
proteins (HSPs), playing a central role in cellular protection and maintenance by aiding in …

[HTML][HTML] Targeting apoptosis in clear cell renal cell carcinoma

A Kowalewski, J Borowczak, M Maniewski… - Biomedicine & …, 2024 - Elsevier
Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal cancer,
accounting for approximately 80% of all renal cell cancers. Due to its exceptional inter-and …

Optimized Microscale Protein Aggregation Suppression Assay: A Method for Evaluating the Holdase Activity of Chaperones

R Tonui, RO John, AL Edkins - Chaperones: Methods and Protocols, 2023 - Springer
Many molecular chaperones act as holdases by binding hydrophobic regions of substrates
to prevent aggregation. Therefore, measuring holdase activity is an amenable method to …

Proteomic analysis identifies HMGA2 as a novel biomarker of overall survival in papillary renal cell carcinoma

T Wei, H Xu, H Liang, Y Lian, H Chen, Z Zheng… - Cancer …, 2023 - Wiley Online Library
Purpose Although papillary renal cell carcinoma (PRCC) has a relatively favorable
prognosis, a small number of patients with lymph node or distant metastasis have a poor …

[PDF][PDF] 基于网络药理学和细胞实验探讨蟾蜍灵治疗胃癌的作用机制

刘玉玲, 陈利荣, 侯艳香, 王元森 - 天然产物研究与开发 - trcw.ac.cn
To explore the mechanism of action of bufalin in the treatment of gastric cancer based on
network pharmacology, molecular docking and cellular experiments in the study. The …

[PDF][PDF] The mechanism of bufalin in the treatment of gastric cancer based on network pharmacology and cellular experiments

LIU Yu-ling, C Li-rong, HOU Yan-xiang… - NATURAL PRODUCT … - trcw.ac.cn
To explore the mechanism of action of bufalin in the treatment of gastric cancer based on
network pharmacology, molecular docking and cellular experiments in the study. The …