[HTML][HTML] Dissecting the role of protein phosphorylation: a chemical biology toolbox
Protein phosphorylation is a crucial regulator of protein and cellular function, yet, despite
identifying an enormous number of phosphorylation sites, the role of most is still unclear …
identifying an enormous number of phosphorylation sites, the role of most is still unclear …
Breaking the chains: deubiquitylating enzyme specificity begets function
The deubiquitylating enzymes (DUBs, also known as deubiquitylases or deubiquitinases)
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …
maintain the dynamic state of the cellular ubiquitome by releasing conjugated ubiquitin from …
Mechanisms of deubiquitinase specificity and regulation
TET Mevissen, D Komander - Annual review of biochemistry, 2017 - annualreviews.org
Protein ubiquitination is one of the most powerful posttranslational modifications of proteins,
as it regulates a plethora of cellular processes in distinct manners. Simple …
as it regulates a plethora of cellular processes in distinct manners. Simple …
[HTML][HTML] Molecular mechanisms and regulation of mammalian mitophagy
V Choubey, A Zeb, A Kaasik - Cells, 2021 - mdpi.com
Mitochondria in the cell are the center for energy production, essential biomolecule
synthesis, and cell fate determination. Moreover, the mitochondrial functional versatility …
synthesis, and cell fate determination. Moreover, the mitochondrial functional versatility …
[HTML][HTML] Regulating the human HECT E3 ligases
J Sluimer, B Distel - Cellular and molecular life sciences, 2018 - Springer
Ubiquitination, the covalent attachment of ubiquitin to proteins, by E3 ligases of the HECT
(homologous to E6AP C terminus) family is critical in controlling diverse physiological …
(homologous to E6AP C terminus) family is critical in controlling diverse physiological …
[HTML][HTML] Synthesis of modified proteins via functionalization of dehydroalanine
J Dadova, SRG Galan, BG Davis - Current opinion in chemical biology, 2018 - Elsevier
Highlights•Dha in proteins is easily and flexibly accessible under mild conditions.•Dha
reactivity is used in β, γ-C–S/Se/N/C bond-formation and allows 'zero scar'protein …
reactivity is used in β, γ-C–S/Se/N/C bond-formation and allows 'zero scar'protein …
Chemical modification of enzymes to improve biocatalytic performance
Improvement in intrinsic enzymatic features is in many instances a prerequisite for the
scalable applicability of many industrially important biocatalysts. To this end, various …
scalable applicability of many industrially important biocatalysts. To this end, various …
Biosynthesis and genetic encoding of phosphothreonine through parallel selection and deep sequencing
MS Zhang, SF Brunner, N Huguenin-Dezot, AD Liang… - Nature …, 2017 - nature.com
The phosphorylation of threonine residues in proteins regulates diverse processes in
eukaryotic cells, and thousands of threonine phosphorylations have been identified. An …
eukaryotic cells, and thousands of threonine phosphorylations have been identified. An …
[HTML][HTML] Deciphering functional roles of protein succinylation and glutarylation using genetic code expansion
Post-translational modifications (PTMs) dynamically regulate cellular processes. Lysine
undergoes a range of acylations, including malonylation, succinylation (SucK) and …
undergoes a range of acylations, including malonylation, succinylation (SucK) and …
Applications of genetic code expansion in studying protein post-translational modification
J Chen, YH Tsai - Journal of Molecular Biology, 2022 - Elsevier
Various post-translational modifications can naturally occur on proteins, regulating the
activity, subcellular localization, interaction, or stability of the proteins. However, it can be …
activity, subcellular localization, interaction, or stability of the proteins. However, it can be …