Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans
Many unknowns exist about human immune responses to the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2–reactive CD4+ T cells have …
syndrome coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2–reactive CD4+ T cells have …
[HTML][HTML] Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals
Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development,
interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of …
interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of …
Classical CD4 T cells as the cornerstone of antimycobacterial immunity
J Morgan, K Muskat, R Tippalagama… - Immunological …, 2021 - Wiley Online Library
Tuberculosis is a significant health problem without an effective vaccine to combat it. A
thorough understanding of the immune response and correlates of protection is needed to …
thorough understanding of the immune response and correlates of protection is needed to …
Epitope prediction and identification-adaptive T cell responses in humans
Epitopes, in the context of T cell recognition, are short peptides typically derived by antigen
processing, and presented on the cell surface bound to MHC molecules (HLA molecules in …
processing, and presented on the cell surface bound to MHC molecules (HLA molecules in …
[HTML][HTML] Defining antigen targets to dissect vaccinia virus and monkeypox virus-specific T cell responses in humans
The monkeypox virus (MPXV) outbreak confirmed in May 2022 in non-endemic countries is
raising concern about the pandemic potential of novel orthopoxviruses. Little is known …
raising concern about the pandemic potential of novel orthopoxviruses. Little is known …
Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells
The identification and study of antigen-specific CD4 T cells, both in peripheral blood and in
tissues, is key for a broad range of immunological research, including vaccine responses …
tissues, is key for a broad range of immunological research, including vaccine responses …
Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells
JM Dan, C Havenar-Daughton, K Kendric… - Science translational …, 2019 - science.org
“Strep throat” is highly prevalent among children, yet it is unknown why only some children
develop recurrent tonsillitis (RT), a common indication for tonsillectomy. To gain insights into …
develop recurrent tonsillitis (RT), a common indication for tonsillectomy. To gain insights into …
Differential T-cell reactivity to endemic coronaviruses and SARS-CoV-2 in community and health care workers
R da Silva Antunes, S Pallikkuth… - The Journal of …, 2021 - academic.oup.com
Herein we measured CD4+ T-cell responses against common cold coronaviruses (CCC)
and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in high-risk health care …
and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in high-risk health care …
Predicting HLA CD4 immunogenicity in human populations
Background Prediction of T cell immunogenicity is a topic of considerable interest, both in
terms of basic understanding of the mechanisms of T cells responses and in terms of …
terms of basic understanding of the mechanisms of T cells responses and in terms of …
Th1/Th17 polarization persists following whole-cell pertussis vaccination despite repeated acellular boosters
R da Silva Antunes, M Babor… - The Journal of …, 2018 - Am Soc Clin Investig
In the mid-1990s, whole-cell pertussis (wP) vaccines were associated with local and
systemic adverse events that prompted their replacement with acellular pertussis (aP) …
systemic adverse events that prompted their replacement with acellular pertussis (aP) …