Cell transplantation holds immense potential for reversing diseases that are currently
incurable and for regenerating tissues. However, poor cell survival, cell aggregation and …

Brain-derived neurotrophic factor (BDNF), a major focus for regenerative therapeutics, has
been lauded for its pro-survival characteristics and involvement in both development and …

Brain-derived neurotrophic factor (BDNF), a neurotrophin that binds specifically to the
tyrosine kinase B (TrkB) receptor, has been shown to promote neuronal differentiation …

There exists an abundance of barriers that hinder functional recovery following spinal cord
injury, especially at chronic stages. Here, we examine the rescue of breathing up to 1.5 …

The risk for respiratory complications and infections is substantially increased in old age,
which may be due, in part, to sarcopenia (aging-related weakness and atrophy) of the …

A variety of neurotrophic factors have been used in attempts to improve morphological and
behavioural outcomes after experimental spinal cord injury (SCI). Here we review many of …

Background Skeletal muscle displays a marked accumulation of denervated myofibers at
advanced age, which coincides with an acceleration of muscle atrophy. Methods In this …

The application of neurotrophic factors as a therapy to improve morphological and
behavioral outcomes after experimental spinal cord injury (SCI) has been the focus of many …

Acute spinal cord injury (SCI) is a devastating condition that results in tremendous physical
and psychological harm and a series of socioeconomic problems. Although neurons in the …

Spinal cord hemisection at C2 (C2SH), sparing the dorsal column is widely used to
investigate the effects of reduced phrenic motor neuron (PhMN) activation on diaphragm …