Paramagnetic chemical probes have been used in electron paramagnetic resonance (EPR)
and nuclear magnetic resonance (NMR) spectroscopy for more than four decades. Recent …

Pseudocontact shifts in biomolecular NMR using paramagnetic metal tags Page 1 1
Pseudocontact shifts in biomolecular NMR using paramagnetic metal tags Christoph …

In this review, lanthanide chelating tags and their applications to pseudocontact shift NMR
spectroscopy as well as analysis of residual dipolar couplings are covered. A complete …

The two-component dengue virus NS2B-NS3 protease (DEN NS2B-NS3pro) is an
established drug target, but inhibitor design is hampered by the lack of a crystal structure of …

Transient biomolecular interactions are the cornerstones of the cellular machinery. The
identification of the binding sites for low affinity molecular encounters is essential for the …

A considerable limitation of NMR spectroscopy is its inherent low sensitivity. Approximately
90% of the measuring time is used by the spin system to return to its Boltzmann equilibrium …

Pseudocontact shifts (PCSs) generated by paramagnetic lanthanide ions provide valuable
long-range structural information in nuclear magnetic resonance (NMR) spectroscopic …

Unraveling the native structure of protein–ligand complexes in solution enables rational
drug design. We report here the use of 19F pseudocontact shift (PCS) NMR as a method to …

Paramagnetic relaxation enhancements from unpaired electrons observed in nuclear
magnetic resonance (NMR) spectra present powerful long-range distance restraints. The …

The supramolecular interaction between lanthanide complexes and proteins is at the heart
of numerous chemical and biological studies. Some of these complexes have demonstrated …