Osteoporosis is a common metabolic bone disease, influenced by genetic and
environmental factors, that increases bone fragility and fracture risk and, therefore, has a …

Osteoporosis is characterized by the alteration of bone homeostasis due to an imbalance
between osteoclastic bone resorption and osteoblastic bone formation. Estrogen deficiency …

Ethnopharmacological relevance Rheumatoid arthritis (RA) is a chronic inflammatory
autoimmune disease influenced by diverse endogenous and exogenous factors. It is …

MicroRNAs are small noncoding RNAs that can bind to the target sites in the 3'‐untranslated
region of messenger RNA to regulate posttranscriptional gene expression. Increasing …

MicroRNAs (miRNAs), a class of endogenous single-stranded short noncoding RNAs, have
emerged as vital epigenetic regulators of both pathological and physiological processes in …

Targeting microRNAs recently shows significant therapeutic promise; however, such
progress is underdeveloped in treatment of skeletal diseases with osteolysis, such as …

Objectives Identifying blood-based biomarkers that predict treatment response in RA is a
clinical priority. We investigated differential DNA methylation as a candidate biomarker of …

Osteoclasts are specialized bone-resorbing cells that contribute to physiological bone
development and remodeling in bone metabolism throughout life. Abnormal production and …

Bone metastasis is one of the main complications of lung cancer and most important factors
that lead to poor life quality and low survival rate in lung cancer patients. However, the …

Hemophilic arthropathy (HA) is a debilitating degenerative joint disease that is a major
manifestation of the bleeding disorder hemophilia A. HA typically begins with hemophilic …