[Retracted] Apoptosis and Molecular Targeting Therapy in Cancer

M Hassan, H Watari, A AbuAlmaaty… - BioMed research …, 2014 - Wiley Online Library
Apoptosis is the programmed cell death which maintains the healthy survival/death balance
in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced …

[HTML][HTML] NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases

A Abderrazak, T Syrovets, D Couchie, K El Hadri… - Redox biology, 2015 - Elsevier
IL-1β production is critically regulated by cytosolic molecular complexes, termed
inflammasomes. Different inflammasome complexes have been described to date. While all …

[HTML][HTML] Non-cell-autonomous tumor suppression by p53

A Lujambio, L Akkari, J Simon, D Grace… - Cell, 2013 - cell.com
The p53 tumor suppressor can restrict malignant transformation by triggering cell-
autonomous programs of cell-cycle arrest or apoptosis. p53 also promotes cellular …

The mitochondrial pathways of apoptosis

J Estaquier, F Vallette, JL Vayssiere… - Advances in mitochondrial …, 2012 - Springer
Apoptosis is a process of programmed cell death that serves as a major mechanism for the
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …

Mitochondrial membrane permeabilization in cell death

G Kroemer, L Galluzzi, C Brenner - Physiological reviews, 2007 - journals.physiology.org
Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

V Sagulenko, SJ Thygesen, DP Sester, A Idris… - Cell Death & …, 2013 - nature.com
Inflammasomes are protein complexes assembled upon recognition of infection or cell
damage signals, and serve as platforms for clustering and activation of procaspase-1 …

Transcriptional control of human p53-regulated genes

T Riley, E Sontag, P Chen, A Levine - Nature reviews Molecular cell …, 2008 - nature.com
The p53 protein regulates the transcription of many different genes in response to a wide
variety of stress signals. Following DNA damage, p53 regulates key processes, including …

Apoptosis in Alzheimer's disease: an understanding of the physiology, pathology and therapeutic avenues

M Obulesu, MJ Lakshmi - Neurochemical research, 2014 - Springer
Alzheimer's disease (AD) is a devastative neurodegenerative disorder with complex
etiology. Apoptosis, a biological process that plays an essential role in normal physiology to …

[HTML][HTML] Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases

F Martinon, J Tschopp - Cell, 2004 - cell.com
Caspases not only play an essential role during apoptotic cell death, but a subfamily of them—
the inflammatory caspases—are associated with immune responses to microbial pathogens …

[HTML][HTML] BH3-only proteins: Orchestrators of apoptosis

A Shamas-Din, H Brahmbhatt, B Leber… - Biochimica et Biophysica …, 2011 - Elsevier
The BH3-only proteins of Bcl-2 family are essential initiators of apoptosis that propagate
extrinsic and intrinsic cell death signals. The interaction of BH3-only proteins with other Bcl-2 …