[Retracted] Apoptosis and Molecular Targeting Therapy in Cancer
M Hassan, H Watari, A AbuAlmaaty… - BioMed research …, 2014 - Wiley Online Library
Apoptosis is the programmed cell death which maintains the healthy survival/death balance
in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced …
in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced …
[HTML][HTML] NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases
A Abderrazak, T Syrovets, D Couchie, K El Hadri… - Redox biology, 2015 - Elsevier
IL-1β production is critically regulated by cytosolic molecular complexes, termed
inflammasomes. Different inflammasome complexes have been described to date. While all …
inflammasomes. Different inflammasome complexes have been described to date. While all …
[HTML][HTML] Non-cell-autonomous tumor suppression by p53
A Lujambio, L Akkari, J Simon, D Grace… - Cell, 2013 - cell.com
The p53 tumor suppressor can restrict malignant transformation by triggering cell-
autonomous programs of cell-cycle arrest or apoptosis. p53 also promotes cellular …
autonomous programs of cell-cycle arrest or apoptosis. p53 also promotes cellular …
The mitochondrial pathways of apoptosis
Apoptosis is a process of programmed cell death that serves as a major mechanism for the
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …
Mitochondrial membrane permeabilization in cell death
Irrespective of the morphological features of end-stage cell death (that may be apoptotic,
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …
necrotic, autophagic, or mitotic), mitochondrial membrane permeabilization (MMP) is …
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
Inflammasomes are protein complexes assembled upon recognition of infection or cell
damage signals, and serve as platforms for clustering and activation of procaspase-1 …
damage signals, and serve as platforms for clustering and activation of procaspase-1 …
Transcriptional control of human p53-regulated genes
The p53 protein regulates the transcription of many different genes in response to a wide
variety of stress signals. Following DNA damage, p53 regulates key processes, including …
variety of stress signals. Following DNA damage, p53 regulates key processes, including …
Apoptosis in Alzheimer's disease: an understanding of the physiology, pathology and therapeutic avenues
M Obulesu, MJ Lakshmi - Neurochemical research, 2014 - Springer
Alzheimer's disease (AD) is a devastative neurodegenerative disorder with complex
etiology. Apoptosis, a biological process that plays an essential role in normal physiology to …
etiology. Apoptosis, a biological process that plays an essential role in normal physiology to …
[HTML][HTML] Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases
F Martinon, J Tschopp - Cell, 2004 - cell.com
Caspases not only play an essential role during apoptotic cell death, but a subfamily of them—
the inflammatory caspases—are associated with immune responses to microbial pathogens …
the inflammatory caspases—are associated with immune responses to microbial pathogens …
[HTML][HTML] BH3-only proteins: Orchestrators of apoptosis
A Shamas-Din, H Brahmbhatt, B Leber… - Biochimica et Biophysica …, 2011 - Elsevier
The BH3-only proteins of Bcl-2 family are essential initiators of apoptosis that propagate
extrinsic and intrinsic cell death signals. The interaction of BH3-only proteins with other Bcl-2 …
extrinsic and intrinsic cell death signals. The interaction of BH3-only proteins with other Bcl-2 …